STRUGGLING with DEPRESSION, ANXIETY, or BIPOLARITY? LEARNING can really HELP. Start with ARTICLES above or Topics below. Ty! Bill

Is It Your Thyroid? New Developments

How to Prevent Depression

The connection between thyroid disease and the mood and anxiety disorders isn’t breaking news here on chipur. But there’s a new twist to the story you need to know about.

Anyone being assessed for a mood or anxiety disorder needs to have a full medical workup. And there are specific culprits that merit primary attention.

One of these is the thyroid. Traditionally, only big-time thyroid dysfunction was associated with the presence of mood and anxiety issues. But that’s changed.

Subclinical Thyroid Problems

Perusing, I found an interesting article that reviews the link between psychiatric issues and what are called subclinical (“minor”) thyroid problems.

The article features the work of Dr. Russell Joffe, a psychiatrist at the North Shore-Long Island Jewish Health System, and colleagues. Specifically, the work was done with subclinical hypothyroidism (low thyroid hormone output).

The team concluded that its treatment may have a profound impact upon the psychiatric symptoms of millions. Not only that, treatment may prevent future cognitive decline.

The bottom-line, according to Dr. Joffe?

Patients with psychiatric symptoms “tell us that given thyroid hormones, they get better.”

A Thyroid Function/Dysfunction Thumbnail

As you may know, the thyroid (located in the throat) is a gland that produces two hormones: thyroxine (T4) and triiodothyronine (T3). And the bodily functions these two hormones are involved with are many and varied. ‘Course, it would only make sense that when something goes wrong and output is altered, unpleasant symptoms present.

Here’s a handy rule of thumb regarding thyroid hormone output and the mood and anxiety disorders…

Hyperthyroidism (excessive thyroid hormone output) may generate anxiety. Hypothyroidism (insufficient thyroid hormone output) may lead to depression.

We discussed T4 and T3, but what about thyroid-stimulating hormone (TSH)? Produced in the pituitary gland, TSH regulates thyroid hormone output.

“Normal” levels of TSH range from 0.4-5. By the way, the higher the TSH level, the less active the thyroid. Most endocrinologists say a TSH level of 10+ requires treatment.

The Grey Area

Okay, so now we know that the upper end of normal in terms of TSH levels is 5. And anything 10+ calls for treatment. But that leaves a grey area between 5 and 10, doesn’t it?

Though controversial, the thought now is that if an individual is experiencing depressive symptoms – and their TSH is in that grey area – perhaps they should be treated for hypothyroidism.

According to Dr. Thomas Geracioti, professor of psychiatry at the University of Cincinnati College of Medicine…

“If somebody has a mood disorder and subclinical hypothyroidism, that could be significant.”

His opinion is supported by a 2006 study conducted by a team from Anhui Province, China. Brain scans were used to evaluate patients with subclinical hypothyroidism both before and after treatment.

The results showed that tangible improvements in both memory and executive function occurred after six months of levothyroxine therapy.

The Pluses & Minuses

So let’s discuss the grey area controversy I just mentioned. Thyroid hormone treatment can strain the heart and can aggravate osteoporosis in women.

But by the same token, not treating existing symptoms, and their underlying cause, can also strain the heart. And some studies suggest ignoring symptoms and cause can up the risk for Alzheimer’s disease and other dementias.

Aside from all of that, there’s the matter of the overall sense of misery generated by non-treatment.

Let’s Close

I believe, along with other medical testing, a thyroid workup is a must for anyone being assessed for a mood or anxiety disorder. Odds are, nothing dysfunctional will be found. But there’s always that small chance. And if issues exist, so much suffering and frustration will be avoided.

So why not do the safe thing and touch all diagnostic bases?

And as it applies to this particular discussion, according to Dr. James Hennessey, director of clinical endocrinology at Beth Israel Deaconess Medical Center in Boston…

“I personally feel patients with TSH between 5 and 10, especially with psychiatric symptoms, warrant a trial of thyroid medication.”

Something to think about as you address your mood and anxiety woes.

More chipur articles on the biology of depression, anxiety, and bipolar disorder? Tap here. Would you like to see a listing of chipur Feelin’ Better articles? Right here.

  • ls

    Hey Bill! Tried to post when this came out, but it didn’t work. The endos have changed the TSH level to 3 or over…but TSH is really just a measure of the putuitary (sp) gland. Free T4 and Free T3 and antibodies test should also be done to know what the thyroid is actually up to. My doc unfortunately doesn’t do those, but gives thyroid meds to anyone with a TSH of 3 or more if they are having symtoms. Good article though…glad you went into it for others… :)

    • …and I’m glad you chimed-in with clarity.

      The point remains, don’t dismiss the potential role of your thyroid when it comes to mood and anxiety ick. And don’t let your doc blow you off. I guess the other consideration is, don’t build yourself up for an easy answer to your problems. I mean, it would be great if your thyroid is the issue, you take some meds, and all is well. Ummm, but don’t count on it.


  • dancer

    Just because you take thyroid meds does not mean your T4 is being converted to T3. I just found that out after taking both Synthroid and Westhroid  for 5 years. I had half of my thyroid removed in ’07 and have never felt the same since. Fatigue and depression can be caused by lack of T3. So my ob-gyn is changing my thyroid meds to Armour and upping the dose. All this over the course of 6- 8 weeks.
    I hope it will help. Also, so much is still being uncovered about the brain by neuroscience that we can’t make truthful statements about how and why depression settles in the body. And just because something worked for one person does not mean it will work for another. We are unique and complex beings on many levels.