Welcome to Chipur! If you’re struggling with a mood or anxiety disorder, you’ve come to a good place. Dig-in, okay? Thank you for stopping-by. Bill

Advil, Aleve Squash the Effects of Antidepressants!

List of NSAIDS

The results of a new study have dropped a bomb on those enduring depression and anxiety – seniors, as well. But the good news is it can be defused. You gotta’ read this!

It takes a lot for a piece of research to be chipur-worthy. What you’re about to read instantly captured my attention and met my standards.

Perhaps yours?

NSAIDs Squash the Effects of SSRIs

A research team from the Fisher Center for Alzheimer’s Disease Research at The Rockefeller University (New York, NY) have come up with a shocker.

They’re suggesting non-steroidal anti-inflammatory drugs (NSAIDs) reduce the effectiveness of selective serotonin reuptake inhibitor (SSRI) antidepressants.

The results of the work are being published in the online edition of the Proceedings of the National Academy of Sciences. The research was supported in part by grants from the National Institute of Mental Health, the National Institute on Aging, and the Fisher Center for Alzheimer’s Research.

Let’s make sure we have a good fix on the meds we’re talking about here…

The NSAIDs are used for pain relief, fever reduction, and the reduction of inflammation. Best known are aspirin, ibuprofen, and naproxene.

The SSRIs, used to treat depression, the anxiety disorders, and other situations include – fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), escitalopram (Lexapro), citalopram (Celexa), fluvoxemine (Luvox), and vilazodone (Viibryd).

Here’s a link to the SSRI piece in my antidepressant need-to-know series. And click here to read an article I wrote on the brand-spankin’-new Viibryd.

Is It the Reason Your SSRI Isn’t Working?

The cat’s out of the bag. The SSRIs, as well as other antidepressants, don’t work equally as well for everyone. In fact, they simply don’t work for many. That may be for any number of reasons; our featured research – perhaps – introducing one of them.

Are you using an SSRI and not getting your desired results? Do you frequently use NSAIDs?

Now, I’m not one to cavalierly introduce false hope. I mean, the NSAID piece may have nothing to do with the ineffectiveness of your SSRI.

But if the shoe fits, wear it and walk in it for a while. Perhaps it’s time to talk things over with your physician or psychiatrist. It sure seems to me that informal testing – and adjustments – would be easy to facilitate.

And you just never know – this time around the good guys/gals may just win one.

The Seniors/Alzheimer’s Connection

The SSRI/NSAID issue is particularly relevant to seniors. Let’s take a look at some important pieces of information…

  • Depression is common amongst seniors – they take SSRIs.
  • Seniors frequently suffer from arthritic and orthopedic misery – they take NSAIDs.
  • Recent research suggests NSAIDs may aid in the prevention of Alzheimer’s, as well as hinder its progression – seniors take NSAIDs.
  • Geriatric depression is a risk factor for Alzheimer’s – seniors take SSRIs.
  • But wait! NSAIDs reduce the effectiveness of SSRIs.

Do you see a frustrating cycle here? What an interrelationship! And now we find out that NSAIDs inhibit the effectiveness of SSRIs.


The Close

I’ve always believed antidepressants – SSRIs, SNRIs, TCAs, etc. – in and of themselves aren’t the ultimate answer to mood and anxiety woes. The addition of therapy creates such a powerful one-two punch.

However, if you’re using an SSRI, why not do all you can to make it as effective as possible? Again, if you also use NSAIDs, chat with your physician or psychiatrist.

As always, always, always – the course and treatment of your disorder is in your hands. Take action!

  • Ck

    Can you please provide a link to the research you’re quoting?

  • Hi Eileen!

    Really glad you stopped-on-by and shared with us. I say it time and time again – the more comments we have the more we can offer those who happen by to learn – and find relief. So, thank you, k?

    Smart move, hitting genesight.com. Personalized medicine is where it’s at – and where it will be for a long time to come. It’s a young science; however, I look for it to mature and bring lots to lots of folks. Ran a piece on the subject a year and a half ago. Even mentioned Assurex Health, who offers genesight. Here’s a link http://chipur.com/depressed-which-antidepressant-is-right-for-you-enter-genetics/

    Regarding Viibryd’s side effects – I more than understand your concern; however, everyone has a side effect story (he says respectfully). No doubt, Viibryd – any antidepressant – can cause buckets of problems for some. Yet for others, no sweat. As you prob know by now Viibryd is a combo antidepressant – an SSRI (like Lexapro) and a 5-HT1A receptor partial agonist (like Buspar). Here’s a Chipur piece on 5-HT1A receptor agonists http://chipur.com/5ht1a-receptor-agonists-relieve-depression-and-anxiety-what-are-they/

    Continue being a vigilant mother, Eileen. But you just never know, your son may have no lasting side effect probs with Viibryd. No doubt, may be some in the beginning, but perhaps they’ll fall by the wayside.

    Thank you for your visit and participation…

  • Gilda Sanchez

    Hi Eileen:

    Reading reports of the side effects is good for information, but keep in mind that the side effects are noted as cautionary for guiding the doctor and patient. A drug will metabolize somewhat differently in each person, due to many variables. You may or may not see each and every side effect in your son. Keep track of the cross-tapering and you might what to study some references regarding SSRI’s in general. The wikipedia reference is a good start: http://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor.

    • Good info, Gilda. Appreciate your visit and input…