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L-methylfolate & Depression: More Good News

L-methylfolate & Depression: More Good News

“I‘m ready to start an antidepressant. If only there was something that could give me a jump-start. Then I’d really be on my way!”

This past February I ran an article on the benefits of using L-methylfolate as an add-on to an antidepressant regimen. Here’s a link to that piece.

The conclusions of a brand-new study bring more good news.

What is L-methylfolate?

Tons of information in the original article, but here’s a quick refresher…

Folic acid is a form of Vitamin B9. Naturally occurring, it’s known as folate. Leafy vegetables are a primary source, along with fortified cereals and breads.

L-methylfolate (actually, L-methylfolate2) is a form of folate. And it’s the only form that crosses the blood-brain barrier.

A rich source of L-methylfolate is the medical food Deplin. It’s available by prescription only, and thought to be safe with very few side effects – if any.

And the Study?

For those who were receiving an inadequate response from their selective serotonin reuptake inhibitor (SSRI) – Prozac, Paxil, Zoloft, Celexa, Viibryd, etc. – Deplin significantly improved the benefits of the med.

What’s really very cool is we’re talking dietary management here.

The report was given at the American Psychiatric Association Annual Meeting, which began this past weekend.


I was impressed by the potential benefits of adding L-methylfolate/Deplin to an antidepressant regimen when I wrote the article back in February. I’m even more impressed now.

Gotta’ keep you posted on fresh news. So take this up with your psychiatrist or physician!!!

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