Viibryd: A new antidepressant, but anything exciting?

should i try Viibryd

Well, another antidepressant is about to hit pharmacy shelves. That’s always exciting news. But what is it? Is it anything to write home about? Chipur strives to bring you the latest – objectively. So, let’s take a look…

The U.S. Food and Drug Administration (FDA) has approved vilazodone (Viibryd) for the treatment of adult major depressive disorder. And that means it’ll hit pharmacy shelves between now and May 31.

I’ve decided to maintain an ongoing journal of Chipur readers’ experiences with Viibryd. I think it’ll be helpful.

Viibryd is a selective serotonin reuptake inhibitor (SSRI) and a 5-HT1A receptor partial agonist. More on that in a short.

Viibryd is marketed by Clinical Data, Inc., Newton, MA. It was announced a week ago that Forest Laboratories, New York, will be acquiring Clinical Data.

An easy neurochemistry lesson

Viibryd: A New Antidepressant

Neural synapse

To the left, you’ll see a drawing of a neural synapse – the actual communication between two neurons. It’s facilitated by the transmission of a chemical/electrical signal. The arrows mark the flow.

Do you see the receptor site on the neighboring (receiving) neuron? Well, receptors are proteins that actually do the sending and receiving of signals.

A 5-HT receptor is activated exclusively by the neurotransmitter serotonin (chemically known as 5-hydroxytryptamine or 5-HT), and it can tweak and regulate the release of a variety of neurotransmitters and hormones – not just serotonin.

5-HT receptors are involved in functions and responses such as aggression, anxiety, learning, thinking, memory, mood, nausea, regulation of body temperature, and sleep.

Now, a 5-HT1A receptor is the most widespread of the 5-HT receptors. 5-HT1A receptors are prominent in high densities in all sorts of mood and anxiety relevant places, including the cerebral cortex, hippocampus, and amygdala.

Activation of 5-HT1A receptors decreases blood pressure, heart rate, and body temperature. Other activation effects include decreased aggression (or an increase in calm behavior), increased sociability, inhibition of addictive behavior, and the facilitation of sexual behavior and arousal.

On the other side of the coin, activation of 5-HT1A receptors generates increased impulsivity, inhibition of penile erection, and the impairment of cognition, learning, and memory.

Okay, one last morsel of biochemistry. An agonist is any chemical that binds to a receptor and triggers a response by that cell.

Lesson over. Let’s see how it applies to Viibryd…

What is Viibryd?

According to the folks at Clinical Data, Viibryd is a “new molecular entity.” What makes it “new” is it’s the first selective serotonin reputake inhibitor (SSRI)/5-HT1A receptor partial agonist.

Most of us are familiar with the SSRIs – fluoxetine (Prozac), citalopram (Celexa), paroxetine (Paxil), etc. Learn more about the SSRIs.

And now we know about the 5-HT1A receptor partial agonist piece. By the way, for our purposes, let’s not worry about the “partial” bit.

But to fully understand the action of Viibryd we have to dig just a bit deeper.

Ever hear of the atypical antipsychotic, aripiprazole (Abilify)? If you don’t have personal experience with it, you may have seen it in a TV or print ad.

In addition to treating symptoms of schizophrenia, mania, and mixed mood episodes; Abilify is touted as an add-on to antidepressants for treatment resistant depression.

Heavily involved here is overcoming a characteristic of serotonin-impacting antidepressants (like the SSRIs). It’s called therapeutic lag. Simply, it can take some time for them to work.

So, an antidepressant regimen that can somehow pick-up 5-HT1A partial agonistic properties brings faster relief and greater overall efficacy.

Oh, did I forget to mention that Abilify is a 5-HT1A receptor partial agonist – just like Viibryd? So, it appears as though Viibryd was designed to handle the work of two medications.

Risks and side effects

As with most any med for an emotional and mental health disorder, Clinical Data states, “The mechanism of the antidepressant effect of Viibryd is not fully understood.” Yep, certainty not surprising.

I’m not going to get into specific details regarding risks and side effects. Instead, have a look at Viibryd’s medication guide and prescribing information.

I will, however, make three comments…

  • Viibryd is touted as having fewer sexual side effects than other antidepressants.
  • I’m concerned about the following effects of activation of 5-HT1A receptors: increased impulsivity, inhibition of penile erection (I thought there were supposed to be fewer sexual side effects), and impairment of cognition, learning, and memory.
  • If Viibryd and Abilify are both 5-HT1A receptor partial agonists, do the risks and side effects of Abilify need to be considered?

The wrap up

So, there’s a look-see at the new antidepressant vilazodone (Viibryd). Interesting? Yes. Unique? Yes. Will it work for some? Yes. Will it aggravate others? Yes. Does it make me jump up and down in excitement? Um, I’ll hold my reaction until I receive input from users.

By the way, I’m simply offering information and opinion here, not making a recommendation. Using Viibryd is a personal decision.

But now you have enough information to perhaps have piqued your curiosity. And if it was, you can conduct additional research. And then it’s time to chat with your physician, psychiatrist, and therapist.

Plenty more mood and anxiety disorder related articles just waiting for you. Hit the Chipur titles.

  • TR April 15, 2011, 2:54 am

    I appreciate some of the facts the author is talking about but his reference to Abilify is not accurate. While Abilify does have a partial agonist affinity to the 5-HT1a receptor it also has the following binding properties.

    D2 Partial Agonist (Ki = 0.34 nM)
    D3 Antagonist (Ki = 0.8 nM)
    D4 Antagonist (Ki = 44 nM)
    5-HT1A Partial Agonist (Ki = 0.34 nM)
    5-HT2A Antagonist (Ki = 0.8 nM)
    5-HT2C Partial Agonist (Ki = 15 nM)
    5-HT7 Antagonist (Ki = 39 nM)
    SRI (Ki = 98 nM)
    Antihistamine (Ki = 61 nM)
    α-adrenergic antagonist (Ki = 57 nM)
    mACh receptor antagonist (IC50 >1000 nM)

    Therefore drawning any conclusions to Viibryd having some of the same possible side effects has Abilify is irresponsible.

    • chipur April 15, 2011, 3:21 am

      Thanks for visiting chipur, TR, and commenting. Your perspective is well taken and appreciated. Only one point of order. Here’s my statement regarding some of the same possible side effects as Abilify: “If Viibryd and Abilify are both 5-HT1A receptor partial agonists, do the risks and side effects of Abilify need to be considered?” No irresponsible conclusions were drawn – I only raised a question. And it seems as though you very nicely answered it – which I appreciate. Again, thanks for your visit and comment!

  • chipur May 4, 2011, 8:17 pm

    A chipur reader emailed me with comments regarding this article. She even found a spelling error. In the spirit of helping others, I asked if I could anonymously share what she had to say. She gave the O.K…

    Found your blog while hunting for info on side effects of new med. The English major would like to ask you to change “peak” to “peek.” After 20 years of not being able to have normal sex on account of, first, tricyclics, then, Nardil, then Prozac, then zoloft, cymbalta, etc etc etc, I am waiting more than eagerly, but without undue optimism, to gulp down this new antidepressant. I note two things: each time a new anti comes out, it’s touted as being less likely to cause SSE (sexual side effects); and also, three percent of the test pilots reported SSE, which is probably more like 99 percent in real life. (As my psychiatrist says, when pts come in and tell him they don’t have SSEs, he asks them: are you TAKING the medicine??!!) Oh well. I’ll try anything once! I’ll let you know what happens.

    I wrote back and thanked her for her email and the spell check. She replied…

    Hi Bill,

    Thank you for writing again. I’ll be first in line at the pharmacy to try the damn thing.

    I used to try the so-called “drug holiday,” but it takes two full days before your normal sexual response comes back, and by that time you’re pretty much also seeing little green men. I remember the first time I took antis, back in 1983. I knew nothing about them. Nothing. I had a boyfriend at the time, with whom I had wonderful sex, but after I took the antis I couldn’t reach orgasm, of course, so I went back to the shrink and said, What gives? And he said, “Well, what do want, orgasms or mental health?” And I said, “Gee, I thought they were somehow connected.”

    Turns out, we were both right: They are connected; that is the choice.

    I’ll send you a full report as soon as I get my mitts on the pills. Drat–not til late summer.

    Give my love to Michigan. I spent many a happy year on the UP.

  • Don May 18, 2011, 1:59 pm

    Hi Bill,

    I was wondering how you found out that Viibryd won’t be released until mid-summer (the post above says late summer). I’ve been searching online and haven’t been able to find any information on a release date for the US. Thank you! Btw great site – I love it!


    • chipur May 18, 2011, 3:51 pm

      Hi Don! Sure appreciate your visit and comment. Glad you’re enjoying chipur.

      Boy, the real Viibryd scoop is tough to come by. I forget my original source, but let’s try this one on for size – from Bloomberg Business Week…

      “Earlier this year Forest paid $1.2 billion to acquire Clinical Data Inc. and Viibryd, a depression drug Clinical Data developed. Viibryd was approved in January and Forest expects it to reach the market by the end of June…”

      Here’s a link to the article –

      I’ll do all I can to stay current and post updates. Thanks again for your visit and comment.

      • Don May 18, 2011, 10:06 pm

        HI Bill, 

        The reason why I was wondering when Viibryd would be available is because I am going through depression right now and I have an appointment to see a doctor this week. I heard about Viibryd’s low side effects and thought it would be a good antidepressant to start off with. Now that I hear that it won’t be out until summer I’m wondering if I should wait to start Viibryd or if I should just try another antidepressant. Help!

      • chipur May 19, 2011, 1:43 am

        Great question, and I empathize. Before I offer my opinion, I want to make sure you know I’m a therapist, not a physician. That said…

        Viibryd sounds like a nice medicine. It’s an SSRI (Paxil, Zoloft, Prozac, etc.), but it has an additional mechanism – the 5-HT1A piece. So it’s different. Of course, the manufacturer is touting few, if any, sexual side effects – according to clinical trials. I’ll truly believe that when I hear it from users several months after it hits the shelves.

        If you’re having a tough time with depression another six weeks can be a loooong time to wait. I’d chat with my physician/psychiatrist about starting on an SSRI with fewer side effects (Luvox, Zoloft) and switch when Viibryd comes out. And don’t forget, there is no generic for Viibryd and I’d bet the farm on it being pricey.

        So there you have my humble opinion. And by the way, I’m hoping you see a therapist. You can’t rely solely upon meds…

      • Don May 19, 2011, 11:44 am

        Hi Bill,

        Thanks for responding. Sounds like great advice to me. I’m going to the hospital today to talk to a provider and I will keep the information you gave me in mind when I speak to them. I know that searching for the right mental health medications is a trial and error process but I’m trying to make as much of an informed decision as possible when I go in. Hopefully they know what they’re doing.

        I’m also going to see a therapist as well. Thanks again!

      • chipur May 19, 2011, 3:36 pm

        Glad to be of assistance…

      • california shrink July 15, 2011, 4:09 am

        One psychiatrist’s comment – I would not wait for the latest and greatest – it take a while to figure these new medications out. For example, often the dosing is skewed. One is far better off using something tried and true and well known to the prescriber. Experiment with new stuff when tried and true does not work. 

      • chipur July 15, 2011, 6:53 am

        Welcome, california shrink – and thank you for participating. Always looking for any and all perspectives…


  • LHSTYLIST8 May 24, 2011, 9:12 pm


    • chipur May 25, 2011, 1:42 am

      First of all, I’m glad you “love” my newsletters – that means a lot to me. I enjoy putting them together. I remember well your new therapy relationship. Sorry it’s gotten off to a disappointing start. If you’re getting the feeling she’s really not paying attention, something is definitely wrong. It’s your right to be very direct with her – lay it on the line. She needs to know you’re having a difficult time connecting. After you make her aware, I’d give her two more sessions to react. If she doesn’t come through, it’s time to go elsewhere. Some time ago I did a series on how to find a good counselor. Here’s a link: Do some reading and let me know what you think. Regarding new meds. The newest antidepressant, Viibryd, is different. Sure it’s an SSRI, but it has another property that adds a new dimension. Check-out the piece I wrote on it: On the other side of the coin there’s Pristiq (desvenlafaxine). It’s predecessor was Effexor (venlafaxine). Did the fact that the patent was running out on Effexor have anything to do with Pristiq coming along? Hmmm. I sure appreciate your visits and comments. Keep us posted…

    • Jessica Hendrix July 19, 2011, 4:08 pm

      You are definitely not alone in having a hard time connecting with your therapist. I’ve had a couple that I’ve felt aren’t paying attention to what I’m saying and are constantly asking me “how does that make you feel?” It feels like they are just there for the $$$ and that’s it. If you don’t like your therapist don’t give up, there is one out there that you’ll be able to connect with. Good luck!

      • chipur July 20, 2011, 6:03 am

        …like me. I do eCounseling (hint, hint).

  • doctorz June 18, 2011, 3:41 am

    Buspirone (Buspar) has been available for years and is a 5HT1A partial agonist.  Very inexpensive in generic form.  If you’re really interested in trying Viibryd, any conventional SSRI combined with Buspirone might be a reasonable and cheap alternative.

    • chipur June 18, 2011, 2:56 pm

      Thanks for the heads-up, doctorz. Given what I’m sure is an expensive drug (Viibryd), your generic combo suggestion makes a lot of financial sense.

    • Teresa_kindle@ July 2, 2011, 9:00 pm

      Sadly, some therapist are less than helpful for some of us. I think of them as shoes. Does this one fit me? After two visits I can tell if I should be spending my time and money elsewhere. The best luck I have is asking my doctor who they recommend. Or a friend or relative you trust and have confidence in. When you find the “right” one you’ll know. And I am not saying the therapist is bad or wrong. I once went to a pregnant therapist and thought I would not be able to “dump” my problems on a woman ready to have a baby. But nothing was her fault. Also, I don’t like my husband’s therapist. But he does. That’s what matters. Shop around if you can. Being referred has always worked best for me. One more thing, if the office staff is kind and professional, I feel that can say a lot about any health care provider. Good luck!

      • chipur July 3, 2011, 4:44 pm

        Hi Teresa! Welcome to chipur – and thank you for participating.

        Great perspective and tips on therapists. Shoes – I love it! Too bad so many are heels. As it states in my About page (, I made the decision to pursue my passion very late in life. I received my counseling credentials at the age of 51. And I gotta’ tell ya’, I’ve scratched my head many times over why some of my colleagues chose the field – and are still in it. Sure, there are many fine therapists out and about, but one can’t over-emphasize the necessity for an effective search and screening process.


  • Sgibsonbsn June 24, 2011, 7:37 pm

    I was just given a sample of Viibryd from my PCP yesterday and was told I was the first patient to try it in her office and that she has heard great things about it.  I have been on a number of ssri’s, antispychotics, ect with the last being effexor xr. I stopped taking this in the spring because I felt like I was doing a little better but was tired of not having any sexual desire. Now I am being asked to start this new drug but I am very concerned that the cost is going to be prohibitive for me. I have insurance but was reading that some of these new class of drugs aren’t covered.  I hate to start something new and then have it start to work but not be able to afford it.  I didn’t address this with my PCP yesterday because I was actually there for a UTI and feeling very crummy.  I walked away with this new drug and I am hoping that if it actually works, she will provide me with samples for a while.  I don’t know…I am so tired of trying new meds. I’m just praying this will work without all the side effects most of them have.

    • chipur June 24, 2011, 9:44 pm

      Hi There! Sure appreciate your visit and comment. Here’s a link to an update article that will answer your $$$ questions. There’s also a phone number for Forest Labs’ patient assistance program.

      I sure hope things work out for you. I know how tired of the hassle you must be,..

  • Nikkibug731 June 29, 2011, 1:36 am

    Just started Viibryd today. Dr. said I was the first in his office to try the new med. My husband of 20 yrs was killed 8 months ago. I am still raising 3 daughters 18,15, and 4 need I say more on the depression issue!? I have tried several anti depressants since none of them working but one(somewhat) but was to expensive and insurance wouldnt pay. Hope this one works but now wondering if insurance will pay for this one. Will keep you updated

    • chipur June 29, 2011, 1:55 am

      Hi Nikkibug!

      Thank you so much for visiting chipur and commenting. What you’ve endured over the past eight months! And now raising three daughters alone. What a strong woman you are. I hope Viibryd works well for you. My understanding is some insurances cover it. Please keep us updated – and don’t hesitate to ask for emotional support here. chipur readers are a kind lot..


  • momof3 June 29, 2011, 2:42 pm

    Hello, I’ve been taking Celexa for about 1 1/2 weeks, but I’ve been having adverse reactions to it so my doc wants me to try Viibryd.  I’m hesitate to start it since it’s so new.  I was leaning toward Lexapro, but the drug rep highly recommended this new med (of course).  I’m going to take my 3 kids to my mother-in-law’s today and take it there.  I’m hesitate to take something new while home alone with my 3 little ones.   I’m hoping for good results.  I’ll try to keep you posted.  Thanks for all of the info above.  It was very helpful.  God bless ~

    • momof3 June 29, 2011, 2:43 pm

       Hesitant*  Sorry for the error! 

    • chipur June 30, 2011, 4:30 am

      Well Hi Momof3…

      Thank you for your visit and comment. Interesting – Viibryd is marketed by the same firm that market’s Lexapro – which will be going generic next year. But, hey, it could well be a super choice.

      Please do keep us informed on your progress. Your information is valuable to everyone – don’t ever forget that.

      Take good care of those three little ones of yours (I’m thinkin’ you do a fine job)…


  • Debi Bordelon June 30, 2011, 10:40 pm

    Hi! I’ve been on Celexa for 2 weeks and so far no results…other than wanting to eat everything in sight. My doctor is going to start me on Viibryd next week since he thinks there is less side affects with the appetite. Do you have any information on that?


    • chipur July 1, 2011, 3:54 pm

      Hi Deb…

      First of all, thank you for your visit and comment. As you may have already read, we are getting reports of weight gain, bloating, etc. Let’s give it some time – the dust settling a bit.

      Keep us updated on your experience, Deb. Even if we’re all not using Viibryd, those enduring mood and anxiety disorders have to hang together…


  • Daric1754 July 2, 2011, 2:25 pm

    I just started taking viibryd two days ago.  So far, so good!  But the first two days is a low dosage…  so I will keep an eye on this site for sure.

    • chipur July 2, 2011, 6:40 pm

      Hey Daric! Really glad you stopped by and participated. Keep after it, and be sure to come back – share, learn, and grab some support…

  • chipur July 2, 2011, 3:18 pm

    Good morning my wonderful chipur readers. Will be making my daily
    comment replies in a few hours. Don’t want you to think I’m slackin’ off

  • chipur July 2, 2011, 6:27 pm

    Reading more and more comments re lower GI symptoms and feeling spacy…

    Remember, Viibryd is directly influencing serotonin and is a 5HT1A
    receptor partial agonist. Some 80% of our serotonin supply is located in
    the gut, where it’s used to regulate intestinal movements. 5-HT1A
    receptor agonists decrease blood pressure and heart rate.

    I don’t believe these symptoms are permanent for most, but given the action of the med, it’s gonna’ take some getting used to…

    • Layla July 2, 2011, 11:10 pm

      I was prescribed Viibryd and Abilify 2 mg. I have taken Viibryd for a week and there are no sexual side effects for me! Yay! 
      I have not started the Abilify yet. I am wondering why I have both prescriptions if the Viibryd has the 5HT1A, the same as Abilify.
      I am having headaches and feeling weak from the Viibryd so, I’m wanting to wait and see if these side effects go away before I start another new medication. 
      Is there a reason my Doc would prescribe both for MDD? Or is it possible he doesn’t realize they do the same thing?

      • chipur July 3, 2011, 4:53 pm

        Hi Layla (my soon to arrive granddaughter’s name, thank you)…

        Welcome to chipur and thank you for commenting. Good question – Viibryd and Abilify??? Of course, Abilify is a 5-HT1A receptor partial agonist – like Viibryd. But it has its antipsychotic action, as well – which, of course, doesn’t equate to you being psychotic! Perhaps there some other mood effect your doc is looking for. It’s certainly not the most pleasant of prospects, but it’s possible your doc, indeed, doesn’t realize they share the 5-HT1A piece. Were I you, I’d be on the phone tomorrow!


  • Kwood715 July 3, 2011, 2:40 am

    HI! I’ve been on Viibryd ten days now!  WOW no major side effects so far.  I took 20 mg of lexapro for a week with 10 mg of Viibryd.   I was actually able to get up and go to work and be social!  mind you i was having anxiety every morning on just lexapro and the same when i was on Cymbalta.  Which is i had more side effects with Cymbalta.  I’m not sure if you should drink at all on Viibryd.  Im not a drinker to begin with but after only 3 beers (small cans) i was vomiting. but, that’s fine with me!  i don’t have to drink.  So, far i am doing great with it!

    • chipur July 3, 2011, 5:12 pm

      Thanks for your visit, Kwood. Great report. I don’t know that you’re officially not supposed to drink while taking Viibryd – I sure as heck wouldn’t. I think you experienced the results…

  • chipur July 3, 2011, 4:30 pm

    Hi everyone! Just a heads-up. If you haven’t read Viibryd’s Full Prescribing Information, please do. There’s so much there that addresses a lot of the questions and concerns I’m catching in the comments. Hey, I want you to keep coming back – but knowledge is power! Here’s the link

  • Leah July 5, 2011, 8:11 pm

    Hi there! Hope everyone had a good holiday. I just came back from the doc with a pack of Viibryd. I heard about it a few months on a Fibromyalgia/Chronic Fatigue forum. There wasn’t any knowledge of testing done for us but there was a lot of hopeful thinking. I am switching from 90 mgs of Cymbalta. I have been on Cymablta for a few years, switching off to try other things. I just haven’t found anything that really helps with the depression as well as the anxiety and peripheral pain like Cymbalta but it is not enough. We have tried Lyrica but that gave me a depersonalization issue every day that caused me to remind myself that I was a real person in a real world and could really die. Savella was horrible. I developed serotonin syndrome from that and it took a couple months post-Savella to get my blood pressure back to normal. Every time I moved my body I had a heart palpitation. I couldn’t breath. After xrays we determined that my throat was slowly swelling shut. We thought I had asthma. So, less side effects? Here’s hoping. Any rumors from FMS/CFS suffers on how they are doing, if they have less sensitive chemical reactions such as adrenaline, or if they have any less neurological pain?


    • chipur July 6, 2011, 12:07 am

      Hi Leah…

      Welcome to chipur, and thank you for a well-considered and expressed comment.

      Have you been through tons, or what? Not a whole lot of fibromyalgia or CFS comments as yet. But if I know chipur readers, someone will chime in with something meaningful. And I’ll tell you what. Let me see what I can find that may be of assistance to you.

      Again, thanks for coming on board. Keep coming back, okay?


    • Karen Powers July 8, 2011, 4:26 pm

      Hi Leah and Chipur,

      I too have FM/CFS, and have been looking forward to trying Viibryd.  On Savella, I had the same reaction as Leah– Serotonin Syndrome.  I became manic, and the pain and insomnia increased tremendously.  What attracts me to Viibryd is the 5HT1a effect of lowering blood pressure, heart rate, and body temperature.  I am hoping that these effects will lead to “calmer  behavior,” and more importantly, to bringing the CNS closer to homeostasis.  If it succeeds in doing that, I expect less pain, and consequently a lower dose of pain medications (or no dose at all).  Perhaps I am too optimistic, but I have to keep hoping.  The thought of living with this level of pain for the rest of my life is abhorrent.  I’m going to bet on Viibryd!


      • chipur July 9, 2011, 12:25 am

        Hi Karen…

        And I’m going to bet on you! You connect the dots well with the ultra-complicated biochemistry involved here. Even more admirable is your spirit. Anyone who says, “…but I have to keep hoping” is tops in my book.

        Thanks so much for your visit and comment…


  • doctorz July 5, 2011, 9:17 pm

    Leah, I’m wondering if you had more noradrenergic hypersensitivity to the Savella rather than serotonin syndrome.  If SS was confirmed, I would be wary of taking any SSRIs, since they’re more serotonergic than Savella, especially considering the additional 5HT1A partial agonism with Viibryd (incidence only reported as 0.1% in the package insert, however). 

    • chipur July 6, 2011, 12:18 am

      Hi doctorz! Nice to hear from you again. You know, I replied to Leah just minutes ago. Told her we haven’t heard much re fibromyalgia or CFS and Viibryd, but I’d bet someone would find something helpful to offer. And here you are. Much appreciated. I’ll let Leah know by email of your reply. Gracias!!!

  • Leah July 6, 2011, 12:07 am

    It wasn’t confirmed, really. I went to my doctor 3 times with these complaints and more and they just acted like I had lost it. I found that SS was a possible side effect and the description seemed pretty similar to what I was experiencing so I stopped taking Savella. I have been on so many serotonin involved medications that I questioned my self diagnoses but I slowly went back to normal. Other than the essential tremor I have been diagnosed with since. It’s been a year with the tremor. 
    Agitation or restlessness
    Fast heart beat
    Loss of coordination
    Overactive reflexes (Still have this)
    Rapid changes in blood pressure
    Heavy sweating not due to activity (this has diminished because I am on a diuretic)
    Mental status changes such as confusion
    Muscle spasms (myoclonus) (Have always had this)
    Tremor (Still have this)
    Uncoordinated movements (ataxia)

    We went through testing for MS shortly after dropping the savella, which was negative. 

    Related to Viibryd:
    I just read that a diuretic could cause issues. I am on a diurectic and potassium for Meniere’s Disease (or endolymphtic hydrops since I don’t have hearing damage). I can’t stop taking it because I was having vertigo and visual drop outs every week and can’t go back to that again. What do I need to do to counteract any issues? Have a bit more sodium? I like salt ;)

    Thanks again!

    • chipur July 6, 2011, 2:37 pm

      Perused Viibryd’s prescribing information. Diuretics are on the list of “Especially tell your healthcare provider if you take” list. So I’m assuming, yes, it could cause “issues.” That said, I don’t get the sense it’s an absolute no-no – like an MAOI. As always, check with your doc…

  • chipur July 6, 2011, 2:55 pm

    You know……………..I wouldn’t just yet. I mean, it’s not like they haven’t stated it could be an issue. My suggestion – give it a few more days.

    I’m glad you’ve found chipur helpful. You’re more than welcome…

  • disneybabe July 9, 2011, 7:59 pm

    I am on Day 2 of my starter pack (10mg). I haven’t had any GI issues (which I totally expected after reading everybody’s experiences here); I took the pill with my regular toast and peanut butter. I am, however, RAVENOUS. Can’t seem to get enough to eat! Also, by 8:00 last night, I was completely exhausted! Totally weird, as I was expecting the insomnia that many people have; I already suffer from insomnia anyway, so was pleasantly surprised to be able to sleep so well! I stopped my Wellbutrin 300mg and Zoloft 25mg 2 days ago, and so far, so good. I guess we’ll see how I’m faring in a few more days…..

    • Frogmen313 July 9, 2011, 11:50 pm

      this sounds so gooood! I am suffering from insomania to after stopping prozac for 5 month! Now I know I can get my sleep back on this pill!

    • chipur July 10, 2011, 6:43 am

      And we’re with you – keep us informed…

    • vibrant July 11, 2011, 5:56 pm

      hi – i’m on day 6 of the starter pack, and me to.!  RAVENOUS.  how can this drug not cause weight gain??  i was on paxil for a long time and went off a few months ago due to weight gain over the past several years.

      • chipur July 11, 2011, 6:21 pm

        Welcome to chipur, and I sure appreciate your participation. I don’t know what I like best – your email or ID name (re Viibryd?). I offered it up earlier, but here’s a link to a piece I did about a year ago on ADs and weight gain.

        Keep sharing!


      • vibrant July 11, 2011, 6:38 pm

        hi Bill – thanks for the reply!  read the article about weight gain.  good info in there. thankyou.    you know i did a search and your site is the only place i’ve found with people trying out this drug.  i appreciate all of the info you’ve listed here.  i like being able to see how other people are doing on it too and compare experiences..

      • chipur July 12, 2011, 2:03 am

        Thanks, oh vibrant one…

        Interesting story. I began following Viibryd back in March – and I continued writing about it because I really believed it was – well – different. Time ensued, and the next thing you know I’m ranked like a champ in Google for Viibryd. Go figure.

        I’m glad you’re finding meaning from my work – and the work and sharing of chipur readers. That’s what it’s all about…


  • Thegman July 10, 2011, 9:58 pm

    i,ve tried every anti deppressant under the sun four and half years ago i found great sucess with cymbalta, buspar and a lil wellbutrin for the sexual side effects worked great i have GAD and stopped working after four years, last year and a half, did zoloft then tried cymbalta again with luvox helped a lil but not much then pristiq, didnt work then lexapro now i talked my PANRP in letting me try viibryd  6 days on it a lil tired. hoping this works i agrreed 3 months ago to 1.25mg klonopin tell we find something because i been sober 8 yrs and didnt waana go on a benzo but i had to work to support my little girl, i hope this viibryd does the trick as im out of options i wont do the atypicals tried those years ago talk about side effects but most psych docs say they have less then ssri i thinlk they need to take anti psychotics before they perscribe them lol

    • chipur July 11, 2011, 5:25 pm

      Here Here! Wouldn’t it be something if a psychiatrist or PCP (without depression/anxiety) agreed to go on a course of Abilify or Risperdal therapy for a time? If he/she wrote one, wouldn’t you love to read the journal?

      • Thegman509 July 11, 2011, 5:48 pm

        I would love to see what real side effects are from zyprexa, seraquil etc… I know they just want to help and I think be size schizo people are a lil anxious they will help others but they are very potent drugs, I only took small doses, they tell me in small small doses they are seratonin boosters, so I hope this viibryd dies the trick be shaw its win loose or draw for me

      • chipur July 11, 2011, 6:15 pm

        Thank you for your chipur visit and comment, Thegman. “…it’s win loose or draw for me.” Explain??? Bill

      • Thegman509 July 12, 2011, 2:02 am

        II’ve tried all the ssri’s friend atypicals years ago I won’t go down that road again lol I tried lamictal, topamax, wellbutrin, everything except pail and serazone so if the viibryd Dosent work I’m gonna just stick with it and hope I don’t get addicted to the klonopin, because switching meds is hell for me because I’m so sensitive to meds so that’s why its win loose or draw for me, I found a nice anxiety treatment center in Tucson but I don’t have 40k

      • chipur July 12, 2011, 2:48 pm

        Thanks for the explanation! If I had 40k extra, I’d get you to Tucson. My respects and empathy go your way. Please feel free to vent, etc. here. You have some caring co-readers (and me)…


  • Jp323nj1 July 13, 2011, 3:50 pm

    Hi Bill,

    I find your writing style very distractive.  Just state the facts, your audience is educated, you write at an 8th grade level, and your comments are too “tongue and cheek”.

    Thank you for taking the time to comment, the information you provide otherwise very helpful.

    Kind Regards,


    • chipur July 14, 2011, 5:32 am


  • diditlive July 13, 2011, 4:39 pm

    hi bill, first-timer….my psychologist mentioned to me the other day that there was a new anti-depressant out (according to a drug rep that stopped by their office the other day) that started with a v and had dual serotonin actions…i did my research today and learned about viibryd and ended up on your informative site…my situation is that after years of failed medical trials dating back to the 80’s, ect treatments, and experimental rtms with dr. george at usc charleston, i’m with a psychiatrist who is stressing treating my anxiety with benzos, valium specifically…he strongly believes in the theory that treating my acute anxiety with benzos (the only sure thing in meds he says, everything else is a crapshoot, his words) will then lead to a lessening of my depressive symptoms and then i will possibly be able to stay away from the anti-depressants and anti-psychotics which have caused me so much trouble with side effects…i’m nearly up to my 20 of valium (10+10) with ambien as needed at night…..i still wonder if this will be enough to help with my depression and ocd….could viibryd work as an adjunct or instead of valium (which does seem to be working)?…i am concerned as stated above that i could not get it without samples from my doc because i am on medicaid and my pharmacist says i might need prior auth which i know i can be hard if not impossible to get..thanks, bill     marc

    • chipur July 14, 2011, 4:55 pm

      Hi Marc…

      Glad you found chipur – and glad you’re participating.

      Okay, disclaimer time. I am a licensed counselor, not psychiatrist. That said, I’ve been around the block many times re my own anxiety disorders over the many years.

      I can see where your doc is going in theory. Yes, an effective benzo regimen would seemingly knock out the need for an AD or atypical. And, yes, they’re both “crapshoots.” And if your depression is largely as a result of your anxiety, it sure seems the matter would be handled.

      Of course, the issue is one of tolerance/dependence. One could wonder where does it end in terms of a dosage that takes care of biz.

      Regarding Viibryd working as an augmenting or instead of agent re Valium – in a sense I suppose that could work, but only if Viibryd is reducing your anxiety. I don’t believe biochemically Viibryd would work as an augmenting agent.

      Re paying for Viibryd. Have you ever used Readers have said it’s on its med roster.

      Hang in there, Marc. Oh, in the future check out this Viibryd article on chipur. It’s where most of the action is.


  • were_all_mad_here July 14, 2011, 9:32 pm

    Hello Bill,
    I came across your site via a Google search on Viibyrd, and I like what I in regards to your website—very informative and helpful stuff. I was prescribed this medication yesterday actually, during my initial visit with my psychiatrist. He said that it is a new drug, with a low chance of weight gain (my weight is a very sensitive issue for me and I fear of gaining) and also low chance of sexual side effects. I said “okay”, and he handed me the sample pack.
     I was diagnosed with depression as a child (8th grade), and did get treatment for a short period of time, but now I have put off getting help for far too long and have finally started seeing someone (I am now in my late 20s). I also suffer from anxiety, but due to abuse of Xanax in the past, my doctor was hesitant to give me any kind of benzo.
    The sample pack my doctor gave me has you take 10mg for the first week, 20 mg for the second week, and then onto the full 40mg dose thereafter.  Today is my second day of dosing. I took the first dose yesterday afternoon, and I experienced gas and diarrhea; I assume this is just my body starting to adjust, since today’s dose (second dose) did not give me the same kind of GI issues as yesterday. I do feel a little tummy ache today, but not like last night. I hope the GI issues will cease once my body gets used to the medication. I also had a lot of trouble falling asleep last night, but I am not sure if that is from the medication, since I usually have trouble sleeping.
    In addition to the minor GI issues, today I also feel a little sluggish and have a little bit of dry mouth.
    I will continue to keep you posted. I am eager to hear how other people react to this new drug.

    • chipur July 15, 2011, 6:42 am

      Hi We’re All Mad There!

      Thank you for visiting chipur and for your participation. I hope you will, indeed, continue to keep us posted. Everyone’s comments work toward the greater good…


      • Anonymous July 21, 2011, 1:28 pm

        Thank you for the warm welcome.
        I am feeling good things with this drug. I am on day 2 of the 20mg pills. So far, I have experienced mostly GI side effects—tummy aches and diarrhea—but it is really key to have a decent meal before taking this drug. While taking the 10mg, I had two peaches for breakfast, then took the pill. I had a terrible tummy ache a little while later, so I had some oatmeal to calm my stomach. I felt fine after that. I was scared to go up to the 20, but so far, so good. I have gastric bypass, so I am thinking that I may not need the full 40mg, but I will see and speak to my doctor about it.
        As far as the positives, I am feeling good on this drug. The last time I took an anti-depressant (Prozac) was when I was first diagnosed in 8th grade. I barely remember that time in my life (I wish I kept journals like I do now). Anyway, I am feeling good. I don’t have any more “episodes”, as I call them. My thinking has become more rational. I feel calmer. I don’t know if it is a placebo effect, but I am feeling good.
        I have not been drinking on this drug, which was the doctor’s strict orders, so I am sure that is helping my mood as well. In order to cope with my feelings and thoughts, I would partake in various self-destructive and addictive behaviors. I am learning through therapy that is not the way to cope.
        I just wanted to give an update. I am feeling really good, and I am happy that my mind is starting to get in order (somewhat).

      • chipur July 21, 2011, 4:29 pm

        Hi were_all_mad_somewhere over there…

        I love that (somewhat) qualifier at the end. Who can’t relate to that?

        What a report! Keep up the good and hard work, and continue to keep us posted on your progress…


  • Thegman509 July 15, 2011, 7:34 am

    Hi bill its ne again I have a question when I switched to viibryd from lexapro besides not getting much benifit from the lexapro and it made me really fatigued, wich I don’t get cuzz 7yrs ago it didn’t have that effect but now I’m on day four of the 20mg viibryd and had to switch to night time and I’m still tired do you think this will pass in time, I read that viibryd was suppose to cause insomnia? I have bad anxiety I could add welbutrin I have in the past for energy but not unless my anxietys under control because well utrin can make my anxiety worse what can I do for the fatigue thanks the gman

    • chipur July 16, 2011, 12:00 am

      Well, I can’t say for sure – but I see no reason why it wouldn’t pass. Can you think of other side effects from previous meds that ended up passing? Betcha’ can…

      • Thegman509 July 18, 2011, 6:18 pm

        Well reason why I ask is, 7yrs ago ssri zoloft and luvox worked and they made me a lil tired so i would take it at night and is be fine the next day, I took lexapro I. The past and it made me wide awake, then I room cymbalta, buspar and 150 mg wellbutin ,l for 4yrs then it pooped out on me since then I tried those ssri’s I list above again and they make me so tired and fatigued that I had to stop fLing them and they didn’t help my anxiety at all so I’m worried S viibryd is my last option I still have hope but I’m scared I’m not going to get this anxiety under contol again, its been along year and a half. 9 years ago this was why I never wanted to quit drinking even though alcholol destroyer my life and every one Round me it worked for anxiety and now I’m 8 1/2 yrs sober thisis hard

      • chipur July 18, 2011, 9:48 pm

        8.5 years sober – well done! I drank like a fish because of my anxiety. Working on 27th year of sobriety…

      • Thegman509 July 22, 2011, 5:58 am

        Question I been on 1.25 mg of klonopin I take .25 4-5 times a day and been on it since April untill I can find an anti deppresant that works so far no results I worry about coming off it if I don’t find something else works and if I loose my sobriety I’m fucked I font think I’d beable to go through that again, so every one tells me ill be fine when its time to come off the klonopin but its the only thing that keeps me going to work and raising my kid so I hope this viibryd works or there’s nothing else out there tried pretty much everything, day 4 on 40 mg of viibryd so far not helping my g.a.d his tired and fatigue

  • Terrysart July 15, 2011, 6:21 pm

     I had posted 2 other negative comments but have not seen them on the blog. I want others to know they are not alone with the bad side effects  I took viibryd for 12 days –  never felt worse in my life! Everything form nausea, diarrhea, extreme fatigue, headachy, lethargic, unmotivated depressed, vision changes. The SE’s continued and new ones were added as the time on the drug increased. I did not feel any inkling of the positive, In fact, I felt more depressed, maybe because it made me feel miserable. I had taken other AD’s and never felt such numerous side effects for so long. I called my doctor and decided to try some  exercise and yoga as natural mood lifters. I started thinking, if I feel so bad now, what is this drug doing for me in the long run. i would say if you absolutely need it, give it your best shot, but it wasn’t for me.

    • chipur July 15, 2011, 9:15 pm

      Hi Terrysart…

      Want you to know I checked all comments – even those flagged for one reason or another. Everything’s been published.

      I appreciate your report, and would be the first to underscore your point that Viibryd isn’t for everyone. Sounds like yours was a well-considered and good decision.

      Thank you for participating…


  • chipur July 16, 2011, 12:15 am

    Well, thank you, MaureenHeather!

    You know, it’s interesting. I’ll be the first to admit I lean toward the sensitive. Okay – I’m sensitive!

    What my critic had to say wasn’t easy to read. I mean, who doesn’t want their guests to like them – and their style of hospitality and expression? But then I came to realize that it’s me that’s chosen to write publicly. And if I’m going to do that, I have to be able to take a few punches – for the cause.

    What I wrote in reply was nothing like what I wanted to write – at first. BUT, it was his right to express how he felt. And for me to have allowed my sensitivity to direct my behavior would have been a huge mistake.

    You’re sweet to have provided comfort. Most of us are that way, you know?


  • vibrant July 16, 2011, 11:00 am

    hi all.  just checking in.  i’m on day 10 or so – 20 mg.  my dr. wants me to at least try the 40.  yikes!  anyone else taking the plunge with me?   i think at 20 i may be sweating a bit more.  anyone else experiencing this?   GI distress long gone.  still have weird insomnia (which i never have).  waking 2/3 times a night for about 10 minutes.   vivid dreams too.  (not like when i came off paxil – had terrible morbid nightmares – yay!)   i feel kind of ‘tired and wired’ at the same time all day.  that’s the best i can describe it.  sure am getting a lot done around the house.  paxil never gave me this energy.  but i’m not completely sold on this drug yet.  we’ll see….

    • Tnkrbllmel July 25, 2011, 12:32 am

      I am on day 10 at 10mg. My dosage is supposed to be increased this week but I can’t let them. I am ITCHY! My lips, my palms, the tips of my fingers. I am weirdly sensitive to prescriptions (Dexilant was the worst. I had welts everywhere), so it may just be me. I am also noticing vivid dreams, which makes it extra hard to wake up in the morning lol. I am on Adderall along with the Viibryd, so I think that may help my fatigue that I heard Viibryd may cause. I get the insomnia sometimes from the Adderall so I can’t really comment on that. I’m going back to Lexapro. I was on that for years with no side affects or allergic reactions. Guess I should stick with what works. Good luck all!

      • chipur July 26, 2011, 12:20 am

        Thanks for joining us, Tnkrbllmel (gotta’ love that name)…

  • 2002s10 July 16, 2011, 3:09 pm

    I started taking Viibryd yesterday… In the past I’ve tried Paxil (terrible), Effexor, Lexapro and Wellbutrin for stress, anxiety, and depression.  Of the SSRIs Lexapro was the best one, with manageable sexual side effects (for the most part), but was expensive when I didn’t get samples.  As a result I was sort of a yo-yo user.  Earlier this year the stress became great enough to stop my sex life completely, Lexapro again helped, but the SSEs were too much so I was given Wellbutrin to try.  there are reports of little or no sexual side effects, but that wasn’t the case for me so I ended up on a very low dose – 50mg a day.  It helped some, but not enough, and I eventually just stopped taking it.  Two months later, its all back – stress, ED, everything.  I went to my doctor yesterday and he gave me Viibryd.  I’m optimistic that it will do what they say it does, without sexual side effects – they only add to the stress.  The only thing I am worried about is cost, but at this point I don’t have a lot of options. 

    • chipur July 16, 2011, 10:23 pm

      Hi 2002s10…

      I’ve never used the service, but am told Viibryd is available through If cost is a concern, check it out.

      Thank you for your visit and comment…


    • 2002s10 July 17, 2011, 6:33 pm

      Day three, not really sure about this one, but its early.  I’m hoping once I get through the 20mg pills I will be feeling much better, and can stay at that level.  The first day it felt like an immediate pick me up, but that may have been my surroundings too.  I tend to think everything is about me, and it affects me way too negatively – Friday night all seemed well in my world.  Like pretty much everyone else, I got the GI issues, headache, and spacey unmotivated feeling – but I usually get that sort of side effects when I start taking anything.  The first night, the ED problem was gone, though I did take a Viagra as insurance.  Day two and three, I feel more stressed, which I fully expect – it’s not a miracle drug.  The headache, spacey feeling, and diarrhea is still here, but its getting better.  Time will tell if this is the right drug… in the meantime I really need to find a way to better deal with my stress.

      • chipur July 17, 2011, 7:33 pm

        Your last sentence speaks volumes! Ding, ding, ding!!!

      • 2002s10 July 18, 2011, 8:53 pm

        Easy to say, not so easy to do.  A lot of it has to do with not talking about what is bothering me – at least not to the right person.  I’ll talk to everyone else… In my mind everything is going to cause a fight, when in reality the discussion is usually a minute long, and the outcome is “I didn’t know it made you feel that way.”  Just need to not hold things in, and stop being a ‘stress bunny…’

        Day four.  Spacey feeling is still there, GI problems are gone, memory seems bad though.  Not sure if I have the insomnia I keep hearing about, I have always had trouble sleeping.  Headache is slight, could be allergies – unless the pill is causing that too.  So far I’m not having any serious side effects, so we’ll see…

      • chipur July 18, 2011, 9:56 pm

        2002s10 – have you been catching the action here?

  • July 17, 2011, 3:16 am

    Well, I will just add this: I was on Lexapro for years. For anxiety and depression.
    Last year I found out I had low testosterone. Was put on Andogel and within 4 weeks was able to stop all SSRIs. Your depressions could be stemming from a hormone imbalance

    • Frogmen313 July 17, 2011, 11:54 pm

      This is my day two on viibryd, i want to know if anyone felt an increase in anxiety? And my insomania still have not lefted, does anyone have the same prpblem? If so how long did it take before the insomania is gone?

      • 2002s10 July 18, 2011, 8:55 pm

        I’m not sure if the increase in anxiety I felt was caused by Viibryd or other factors.  For me it was much worse on Wellbutrin.  Day four I don’t feel much anxiety at all, so hopefully it is just temporary for you.

      • vibrant July 18, 2011, 9:27 pm

        hi – i’m having insomnia too – i’m at 20mg, just about to go to 40.  i rarely have trouble sleeping so the insomnia is weird for me.  i wake at different points at night for about 10 minutes.   i feel like this drug really amps me up – like it never lets my body rest.  anyone else feeling this?  like i’m always humming.  making me very restless at night before bed – like my skin is crawling.  wondering if this will let up….?  definitely not sold on this drug yet. 

  • vibrant July 18, 2011, 9:20 pm

    i agree with this poster Bill!  i find your writing style accessible and personable.  hey if we wanted just the facts on this drug i suppose we could all study our viibryd package inserts instead lol.   yours is the only site i’ve found with people trying out this new drug.  it’s kind of scary trying something that’s just come out and i appreciate being able to read your posts and how other people are responding to the drug.  keep up the good work!

    • chipur July 18, 2011, 10:06 pm

      Thank you, Vibrant. Very kind of you, for sure…

  • Ruca July 19, 2011, 4:15 am

    I am on day 2. I am not having GI issues really, just a steady dull headache and insomnia. I’m hoping that the sleep issues go away with time. If not, I would quit the pill for that reason alone. I need my sleep!

    My main question is if it really has no weight gain issues. I gained 20 lbs while on lexapro and stopped it for that reason and the sexual side effects. 

    • chipur July 20, 2011, 7:35 pm

      Hi Ruca…

      Well, the weight gain biz is not supposed to be a prob, but I don’t think there are any “for sures” when it comes to psychotropics…


      • Ruca July 20, 2011, 10:18 pm

        you are definitely right…nothing is a ‘for sure’…! I would just love for this to work for me. I’m on day 4 and still nothing major in regards to side effects. The headache has seemed to go away, I’m a bit restless at night…and stomach stays a bit ‘rumbly’ through the day. We’ll see how it changes when I up to 20mg. 

        Thanks again for this forum, I’m really enjoying being able to share. 

      • chipur July 21, 2011, 3:52 pm

        I’m so glad you’re finding some enjoyment in sharing here, Ruca. Nothing like it in the midst of icky times. I (we) ain’t goin’ anywhere…

  • Meltorment July 19, 2011, 6:56 pm

    I think I may have took my dose of 40mg twice today by accident.

    • chipur July 19, 2011, 7:01 pm

      Take a deep breath, Meltorment. My gut says no major prob. However, if you’d feel safer call your docs office and ask…


      • Meltorment July 19, 2011, 7:22 pm

        Thanks Bill- I was thinking the same thing. :)
        This site is fantastic and you are the best! Thank you for everything you do.
        Best Regards,

      • chipur July 20, 2011, 7:08 am

        Glad I could help. I enjoy it!

  • vibrant July 20, 2011, 8:16 pm

    hi – i’m at 40 mg today and i feel sooooo restless.  strange tingling in hands and feet.  like my skin is crawling.  thinking of going back to 20 tomorrow.  does anyone know if you can cut the 40 mg in half for the 20?  (i ask because i was on paxil CR and you couldn’t cut those in half to get a true half dose)   anyone else feeling like you could jump out of your own skin??  does it go away?   i’m thinking of bailing on this drug!

    • Ruca July 20, 2011, 8:49 pm

      Vibrant- My psychiatrist told me that if the 40mg was too much, or that I felt better/fine with the 20mg…that I could just have the 40’s. Of course always as your Dr…but I was given the ‘ok’ by mine. I’m only at 10mg (4th day) and I’m pretty sure that 20mg may be my resting place as I am super sensitive to any and all medication. Time will tell though! Good luck. :) 

      • Ruca July 20, 2011, 8:49 pm

        Sorry, ‘half’ not ‘have’. 

      • chipur July 21, 2011, 3:49 pm

        Anyone get an official okay to cut a 40 in half?

      • 2002s10 July 22, 2011, 8:11 pm

        I was also told when given the pack that if I feel fine at 20mg, I can cut and stay there.  At the moment I don’t even plan to try the 40mg. 

      • Sweeneyp August 10, 2011, 12:16 am

        I don’t believe that these pills are “scored”, that is, they have a line down the middle of them.  Whenever you break a pill that is not scored, there is no guarantee that you are receiving 1/2 of the medication on each side of the pill, you may be getting all of the dose on 1/2 and none on the other.  This is the reason that mfr. score tablets, specifically so that they can be cut in half while guaranteeing that half the dose is in each half of the tablet.  This goes for any medication.

      • chipur August 10, 2011, 3:37 pm

        Thanks, Sweeneyp, for an important post. There have been chipur readers who reported getting the green light from their psychiatrist to cut a Viibryd tablet in half.

        But is it really the right thing to do? Check out this article –

        Would like to hear from someone who’s gotten the “OK” from their psychiatrist and an explanation as to why it is.

        Again, thank you, Sweeneyp…


    • chipur July 21, 2011, 3:45 pm

      The “strange tingling” is paresthesia – a known side effect. Hey, if the negatives outweigh the positives, it’s time to fly…

    • Tnkrbllmel July 25, 2011, 12:37 am

      YES. I’m itchy and that is making me irritable. It’s like my insides are itchy and I can’t get to them. Not  cool…..

      • vibrant July 25, 2011, 5:32 pm

        me too!  driving me nuts.  like my skin is crawling.  so annoying.  this drug is funny.  it doesn’t seem to give my body rest… thinking of trying something else at this point.

  • Smudge July 21, 2011, 1:14 pm

    Hi – I’ve tried everything and am on everything : Wellbutrin, Prozac, Lithium, Lamictal, Ativan and now Viibyrd too. I’m on week two and feel nothing, not even side effects – though somewhat speedy. I asked for Celexa and got this. Abilify made me seem drunk. Cymbalta + Zanax caused a suicide attempt – ICU 4 days – 9 days of forced rehab – waste of time. Not going there again yikes! Oh, Viibyrd – I am waiting. I’m supposed to be Bipolar. Huge fear of weight gain though am 5″ 7 and 110 lbs.  Why isn’t there anything?

    • chipur July 21, 2011, 4:22 pm

      Hi Smudge…

      First of all, thank you for visiting chipur and participating.

      Your final line breaks my heart. I’m so deeply sorry there doesn’t appear to be anything for you. If only I had the answer…

      I’m not going to show disrespect for your comment and situation by rambling on – I simply can’t provide anything med helpful. But what I (and chipur readers) can provide are a set of eyes to read what you share, a heart, and a lot of care.

      Please keep coming back…


  • Smudge July 21, 2011, 1:34 pm

    Smudge’s Profile: Been sick all me life (58) nervous, anxiety, depression, social problems – afraid.
    Frequently scared and crying for no reason. Did the drinking (drunk) thing – ten years sober, ten years not smoking, ten years veggie.  

    • chipur July 21, 2011, 4:30 pm

      …ten years working hard. Doesn’t seem fair, does it? Are there things in life you enjoy?

  • Smudge July 21, 2011, 1:36 pm

    Hey, but I look good.

    • chipur July 21, 2011, 4:34 pm


  • Ruca July 21, 2011, 3:26 pm

    Day 5- Headaches are gone. Insomnia is being managed with a Simply Sleep pill. I also take 2 tums to deal with my rumbly tummy. I feel more relaxed and my racing/negative thoughts pass fairly easy. My only issue currently is the constant state of being hungry, it’s insane. But I’m managing that. Also not experiencing any sexual side effects yet. I’m curious to see how my side effects change when I start my 20mg pills. 

    • chipur July 21, 2011, 4:34 pm

      What I especially enjoy about your reports, Ruca, is your creativity and adaptability. Problems pop-up, you seem to find something to manage them. That’s the kind of spirit and drive that sustains a darned fulfilling life…

      PS: No offense, other chipur readers – many of your are doing the same thing. Kudos!

    • were_all_mad_here July 22, 2011, 5:39 pm

      Ruca, I am glad to see other readers with some positive feedback. I feel the same as you where you say: “I feel more relaxed and my racing/negative thoughts pass fairly easy.” I totally relate to that.
      My tummy is rumbly too.. I have been taking Imodium when the diarrhea gets bad. I will try the tums as well. I notice that I am going to the bathroom a lot more often. Hopefully I will lose some weight lol.
      As far as the constant desire to eat, I understand. I don’t really notice a difference, since food has always been a battle with me.
      Glad to see Viibryd is doing well for you. Keep on posting J

  • Molly July 23, 2011, 6:16 pm

    Hi.  This is my first post and I’m not sure if I’m putting it in the right place.  I just wanted to add my experience with viibryd.  I have had anxiety and depression for a long time.  I have tried many different ads, but none have worked. I am on a benzo for the anxiety.  My dr gave me a sample pack of viibryd.  I’m on day 16 (2nd day taking 40 mg). I had not noticed any side effects on 10 or 20, but I have had a headache since starting 40.  I did have a couple of better days yesterday and the day before so I was hoping the viibryd was starting to work.  Today I’m having a bad day again so I’m not sure.  I hate being  on a brand new drug, but I was out of options.  I just pray that this will help.  I do appreciate being able to read everyone else’s experiences and I’ll keep you posted on mine.  Good luck to all of you.


    • chipur July 23, 2011, 7:51 pm

      Hi Molly! Thank you for your visit and participation. You handled everything just fine!


  • magz July 24, 2011, 6:46 am

    I just found this article as I was searching for the answer to whether or not it was okay to cut the Viibryd pills, and not only did I find my answer, but I really appreciate the other post on here about side effects as well. I was sitting here trying to decide if I would even bother continue taking the damn stuff due to the side effects I’ve been experiencing, and if the answer was I couldn’t cut the pills, I don’t think I would have. However, for the first time in a very long time, when not taking the crazy physical side effects, I feel…. right. I don’t know how else to say it. I’m currently about to take day 12, so I’m on the 5th day of 20mg. When it jumped to 20mg, that’s when I started experiencing the side effects, but at the very same time (my second 20mg dose), it was like somebody flipped a switch in my head. It was crazy! I went to bed, in the midst of a deep depression that has been going on for about a month since my last bipolar, rapid cycling “episode”, feeling completely apathetic, and then woke up in the morning feeling good. Then as the day progressed, I started feeling like I was on meth again. I have a long history of addiction, my drug of choice being heroin, and the reason I’m on methadone, but at one point I spent about a year doing meth, and I felt just like I had done a huge line. It’s very frustrating, and I really feel for others who have been searching for something to work, because in my case it seems like every med I try is either a total disaster, or it works, as Viibryd seems to be, but the side effects are too much to take. So again, I’m contemplating whether to continue with this. I am also back on my lithium because this drug seems to evoke my mania, which I prefer over depression, but the lithium seems to be balancing it out. I’m considering halfing the 20’s, but since I didn’t start feeling like me again until I started them.

    My side effects include what some others have mentioned on here, like feeling like your skin is crawling, feeling tweeky, not being able to sleep, the parasthesia, and also every muscle in my body is super tense. Oh, also sweating, dizziness, and I have nearly passed out a number of times, one I even started to fall but was able to catch myself. On top of that, many of the side effects are the same things that happen when you start to withdraw from opiates, and it get’s worse and worse as the day goes on. I believe that the Viibryd is interacting with my methadone, and somehow causing it to not hold me the 24 hrs that it normally would.

    Sorry for such a long post, but that all brings me to a few questions, does anybody know HOW LONG these side effects last before they go away and you even out? Also, I believe most of my side effects are listed, but I was wondering if you knew what might be causing my dizziness, and faintness. My blood pressure is generally pretty low; last time I took it it was 102/56 which is pretty normal for me, could it be a drop in blood pressure from the Viibryd? Could this possibly be dangerous for me? Any suggestions as to what I could do to help with this? It definitely seems like eating helps, but it doesn’t totally make it go away. Okay, one last question. I take my pill at night. It seems like I can’t sleep without taking something to help me, but I’m also very speedy when I get up in the morning (which is happening unusually early now), and some side effects seem worse as the day progresses. When do most people take theirs? My psychiatrist is a very nice lady, but flaky and not very helpful, or I would ask her, but she just kind of throws meds at me or gives me what I tell her to. So anyone have any suggestions?


    • Molly July 24, 2011, 3:26 pm

      Hi Maggie.  I’m sorry to hear you have had so much to go through.  I’ve had a lot of the same side effects as you, but I had a lot of them before  I even started viibryd (from other ads and just from the anxiety).  All that we go through can really be so overwhelming.  Have you considered switching to a new psychiatrist since yours is kind of flaky.  It sounds like you need good sound medical advice, especially with your blood pressure.  I hope things work out for you. Take care,     Molly

      • chipur July 24, 2011, 4:06 pm

        You know, I’ve come to count on the kindness and caring of chipur readers. It’s just too cool, and I’m so proud of you…

        And isn’t it the truth – those who know pain and suffering are generally the first ones to soothe someone’s fevered brow?

        Thanks to all of you…


    • chipur July 24, 2011, 3:52 pm

      Hi Maggie!

      Welcome to chipur – I’m glad you’re participating. No need to apologize for the length of your comment, by the way.

      The length of initial side effects varies so much from person to person, so it’s really hard to make a guess. I’m thinking other chipur readers will chime in, though – as they will re the side effects you mention.

      How ’bout a suggestion? I understand having to know what actually causes a particular side effect is seemingly important – but is it really? If you ask me, the fact that Viibryd manipulates – with two major actions – the all powerful and far reaching serotonin is likely the only explanation anyone would need. Man, anything can happen (relax – within reason)!

      You’re going to be just fine, Maggie. And chipur readers will help you sort through it all, okay?


  • Catie July 24, 2011, 11:46 pm

    I just started Viibryd three days ago, after finally giving in and allowing my psychiatrist to prescribe me something. I ended a 6 year relationship a few months ago and have been having a really hard time – depression, constant crying, horrible anxiety – and I needed to do something so I can function again like a “normal” human being.

    I’m nervous… I hate taking medication, do not really want to be on an AD, and am a little scared to be on something SO new with so little known as far as long-term effects and things like that. I started on Cymbalta, but within two days was a total mess. This stuff, at least at 10mg, hasn’t made me feel that way at all. I am willing to move up to 20mg, but I hope that is where things start evening out for me because I don’t really want to go to 40mg. I don’t even really have a valid reason for not wanting to go to 40, it’s just all mental.. lol

    I’m glad I found this site, though, because it was pretty freaky to be given something where there’s like… NO information anywhere!

    • were_all_mad_here July 25, 2011, 2:59 pm

      Welcome honey. I’m so sorry about the break-up, but just know everything happens for a reason and know good things will come to you.
      I understand your worry about such a new medication, and I can totally relate. I am on my 2nd to last day of 20 mg, and I have been feeling pretty good lately. Aside from some GI issues, I haven’t had any major side effects. Like I stressed in my previous post, it is important to have a decent meal when you take the medicine. I take mine with breakfast in the mornings. My racing thoughts have calmed a bit, I don’t have as many “episodes” as I call them (irrational thinking that gets me very worked up and emotional). My obsessive and panicked thoughts have tamed, and I find myself being able to rationalize them more easily.
      I know what you mean when you say you hate taking medication. If you were a diabetic, would you refuse insulin? It is along the same lines. As far as going to 40mg, see how you feel when you are taking 20mg. I start the 40mg in a couple of days, and I am also a little curious how I will feel. I don’t want to completely reject it, but if I feel it is too much, I plan on speaking to my doctor about it.
      Keep us posted, and keep your head up J

      • Catie July 25, 2011, 10:15 pm

         Thanks so much, I really appreciate you replying! I certainly hope good things come to me, because it sure doesn’t feel like it at the moment :( I think I have the same “episodes” as you do.. something triggers a thought in my head that I start thinking irrationally about and before I know it, I’m a crying mess. And some of it (like feeling guilty and/or remorse for my decision) is stuff I need to work through on my own, but right now I just don’t function like I used to. It’s exhausting spending the whole day at work trying my hardest to not feel anxious, to not start crying for no reason in particular, to pretend like I’m great so I don’t start getting on my co-workers’ nerves. So I’ve tried to ignore my fear of medication and give it a shot :-/

      • chipur July 26, 2011, 12:36 am


        Keep on being you. You’re working so hard and I hope you have a great measure of personal pride and respect right now. Most who have never endured what we do would be dropping like flies!

        PS: I don’t see how you’d get on anyone’s nerves…


      • were_all_mad_here July 27, 2011, 1:36 pm

        You are welcome. I am so happy to have discovered this site and hear how other Viibryd users are feeling.

        That sounds like me, but I am noticing that my episodes have been getting less and less. Speaking with my therapist about my feelings is also a great help too. I just have to take a moment and really think about my irrational thoughts. I don’t know why my brain does that, but I really believe the Viibryd is helping.

        I started the 40mg today, and I have been feeling pretty good. I will keep all posted.

      • chipur July 27, 2011, 4:12 pm

        Ah, the most complicated three pound mass of tissue and fluid known to woman/mankind…

      • chipur July 26, 2011, 12:23 am

        Sweet! Thank you…

    • chipur July 26, 2011, 12:19 am

      Thank you for your visit and comment, Catie (I like the spelling)…

      • Catie July 26, 2011, 12:24 am

        Thanks! :)

  • Molly July 26, 2011, 3:27 pm

    Just checking in.  I’m on day 19 of taking viibryd( 5th day of taking 40 mg).  On some days, I feel like it helps a little bit with the depression and lack of motivation. However, it has not helped at all with the anxiety.  I really feel a little more anxious.  It feels like my body is constantly in a state of high alert.  I try to start doing things, but it makes me even more nervous.  I am also waking up several times a night feeling startled with worrying thoughts.  I’m not really sure if I’ll be able to keep taking this.  I just hope if I have to get off of it, I won’t go through bad withdrawal.   I hope some of you are having better luck with this and finding some relief.


    • Elbabes_06 July 26, 2011, 8:46 pm

      I stopped taking it because it didn’t help my anxiety at all either and even after taking my clonopin for anxiety it didn’t take effect at all which worried me. I also felt more aggression/anger/irritation while on it, for me I’d rather be depressed and sleepy than feel like a bipolar lunatic! It’s frustrating wondering if it will get better if you just stick with it so I’d be interested to see how you progress on it and if it does get better, good luck!

    • Ruca July 27, 2011, 7:59 pm

      Hey Molly, I was doing great on the 10mg…loved the way I felt and then the 20mg came….(I’m on 4th day) and I too am feeling more anxiety…or more easily swayed to anxious thoughts. I won’t be trying the 40mg…and am debating the pill too. 

      Hope it gets better for you! 

    • vibrant July 28, 2011, 12:18 pm

      hi molly – same thing seems to be happening with me.  i feel more amped up on this drug.  great to get stuff done, but more irritable.  i normally never have trouble sleeping and i too wake up several times a night, sometimes physically startled awake – and then have lots of trouble getting back to sleep, even with melatonin.  i know my dr. wants me to give this drug a fair try, but i’m not sold. some days i feel like i might take someone’s head off being on this stuff!

  • Elbabes_06 July 26, 2011, 8:43 pm

    I switched from celexa 40mg to vibryd and the first week I felt a little better despite bad nausea but I only tolerated it because I liked that it made me not eat, but as soon as I started the 2nd week where I no longer included my celexa with the dose I felt very different. I was told to take it at night because it can make people sleepy but it kept me up until 4am even AFTER I took a clonopin which usually calms me pretty well. It gave me more energy but almost felt like a buzzing feeling&I don’t know if it was in my head but I’d see sparkly spots once in awhile. Also I just sort of felt bipolar with mood swings, one day I’d be really upbeat and the next irritated by the smallest things and I’m usually pretty laid back with other people. The second day of taking just the vibryd I had extreme stomach pain and nausea and didn’t even want to go to work&had a stressful day so I had a glass of wine and then I got very depressed and negative and started bawling my eyes out and had suicidal thoughts, that made me decide to stop taking it. Yesterday I did not take the Vibryd and just took my celexa and I feel more like myself but I slept 14 hrs! I’m hoping the sleep thing will regulate, I was hoping it would be my miracle drug after being prozac on years and that not working then trying paxil, zoloft, wellbutrin&cymbalta. It makes me want to just get off the celexa and see what happens! It’s very irritating going into my psych and trying a new medication pretty much everytime, I’m thinking about possibly trying Effexor as my dad takes that but I’m so sick of going through side effects, worrying the new meds will make me fat, suicidal, etc. Ugh!

    • chipur July 27, 2011, 1:40 am

      Hi el_babes, and welcome. I know it’s such a major drag – this meds merry-go-round. Keep us informed, okay? And even if you opt out of Viibryd, you’re info is just as valuable.


    • were_all_mad_here July 27, 2011, 1:32 pm

      Hello Elbabes,
      I am sorry you haven’t been feeling too great. Just keep your head up and try and be positive.

      I just want to warm you, that you should NOT be drinking any alcohol while taking Viibryd. That was a very strict order from my doctor. Due to the 5-HT1A receptor partial agonist component of the med, alcohol can cause you to feel MORE depressed (which is most likely why you felt more depressed and more negative than usual). Even a little bit of alcohol will cause this. I know it may be hard to completely remove alcohol (it was for me, since I was a borderline alcoholic due to my depression), but the feeling of being healthy—mentally and physically—hasn’t made me miss it one bit.

      Keep us posted.

      • chipur July 27, 2011, 4:10 pm

        Spoken like a true leader. Thank you, WA(kinda)MH…

  • Elbabes_06 July 27, 2011, 5:47 pm

    Well the alcohol wasn’t the only negative thing about it. Before that I felt all the other bad things, I felt as though all the other mental issues I could have but didn’t came out lol with the anger/irritability and increased anxiety. I don’t see how I would tolerate the 40mg ever. Yesterday was my 2nd day back just on the Celexa and things are better except I can’t get up unless I sleep at least 12 hrs. Hopefully it’s just my body adjusting.

  • Ruca July 27, 2011, 7:58 pm

    Haven’t posted in a few days so I thought I’d fill you all in!

    I’m on day 11 (4th one of my 20mg) and I’m not sure how I feel about it. 
    I felt amazing on the 10mg. My creativity had come back, no upset stomach…a bit of insomnia…but nothing that I couldn’t deal with. Then I took the 1st 20mg and I’m sluggish…groggy..and I can’t tell if it’s from the lack of sleep or the actual medication. I more moody….headaches….just not liking it at all. 

    I am highly sensitive to medication and I’m wondering if it’s possible (although I know there isn’t much research to prove this) if someone can be on 10mg or if it has to be a higher dose. I go in to see my Dr next week and will be inquiring. I will not be attempting the 40mg. no way. 

    I literally went from the first week of medication, being happy…and excited about this pill…to questioning whether or not this will work for me. 

    No sexual side effects yet, which is a plus. 

    anywhoo! Just wanted to share. 

    • chipur July 28, 2011, 12:31 am

      Thanks, Ruca. So just keep it at 10mg – don’t ya’ think?

      • Ruca July 28, 2011, 2:00 pm

        I hope that’s an option! Although…..late last night it’s like something changed up a bit. I got a burst of energy and was feeling really happy when I went to sleep. Woke up this morning feeling pretty good! I’m going to let the rest of this week pan out and see how my mood stays. 

        Thanks for the response! 

  • Molly July 28, 2011, 4:12 pm

    Just checking in .  I’m on my 21st day of taking viibryd(7th day of taking 40mg).  I seemed to have less depression on the 10 and on the 20.  Maybe I just had high hopes.  It did not help with anxiety,  but since starting on 40mg. the anxiety has gotten soo much worse.  I feel like my insides are vibrating,  having strong heart palps, headaches,  and irritability.  I feel like I’ve given it a fair chance, but I know I can’t stay on 40.  I have a call into my Dr. about splitting the pill.  He hasn’t called back yet, but I already cut the pill and took half. I’m also sweating like crazy and am more depressed today.  Maybe it’s just because I feel so lousy.  Sorry to be so negative.  I just wanted to share my experience. 


    • vibrant August 2, 2011, 7:58 pm

      yes i’m sweating more too on this stuff!  that’s really annoying!  and more irritable too for sure.  

  • scoobysnackn July 31, 2011, 6:36 pm

    Day 4 on the 40 mg…and today I am so grumpy and edgy I could bite someone’s head off! Had a couple of good days going from the 20 mg into the 40’s, but now my G.I. system is a mess, I’ve got heart palps off and on all day, anxiety and nervousness is worse, hair-pulling is at an all-time high, and I go off into ‘stares’ constantly! What is up with this crazy whackjob-of-a-drug?? WHY hasn’t anyone developed a way, after lo these many, many years, to accurately measure the level of a person’s serotonin? Jacking a drug up and down to find the ‘sweet spot’ is archaic at best.

    Is that your best, medical community? Cause your best won’t do…

    I go back to doc in a couple of weeks – let’s all keep fightin in spite of em! ;)

    • Thegman509 August 1, 2011, 3:15 am

      I’m on day 14 of the 40 mg anxiety worse, I was taking it at night, and is wake up several times than Friday I woke up at 2:00am wide awake had to take benadryl to get back to sleep so I decided is take it Sunday morning, and sat night came I didn’t take it tried getting to sleep a night mere, horrible panic attacks body felt wierd when I would sleep for a min total nightmeres,took benadryl melatonin couldn’t sleep I took 40mg this morning and I’m hoping I sleep tonight. I see doc on thee day if not better gonna ask to go back to 20 mg or get off of itI’ve never had a response to a Ned like this except maybe topamax

  • Molly August 1, 2011, 2:30 pm

    I am on day 23 of viibryd.  I took 40 mg for 6 days but was incredibly anxious.  I’ve started cutting the pills in half so am now on 20.  My doctor would like me to stay on 20. I am still very anxious and pretty depressed.  I had high hopes for this med, but am disappointed.  I don’t like the way I feel on it.  I’ll still keep trying the 20, but I don’t know for how long.  My Dr. also told me he gave out 3 sample packs and his other 2 patients also had a lot of trouble on 40 mg.  I hope at least some of you find relief on this med.  Living with anxiety and depression is so very painful.  My best to all of you.


    • chipur August 1, 2011, 3:55 pm

      It is painful, isn’t it? I’m sorry you’re not getting the relief you expected, Molly. It just ain’t fair!

      • Molly August 1, 2011, 7:37 pm

        Thanks Bill.  I do want to say that I really appreciate your site.  You have a lot of good information.  I’m so glad to be able to share with others who are also trying Viibryd.  I haven’t been able to find reviews like this anywhere else.


      • chipur August 2, 2011, 2:09 am

        Well, you’re more than welcome, Molly. Thanks for the kind words. Ain’t goin’ anywhere, so visit and contribute as you can – it’s valuable to all…


  • chipur August 2, 2011, 2:02 am

    Just posted a brand new piece on catastrophizing. I know you’ll find it helpful.

  • Molly August 2, 2011, 4:44 pm

    Just checking in.  I’m still having a hard time on Viibryd.  I’m feeling more depressed and way more anxious.  I’m also feeling shaky, dizzy, and weak with a constantly pounding heart.  I’d like to know if others are having heart palps on viibryd.  I’m calling my Dr. today to see about getting off.  I hope others will keep posting their experiences.  It’s so valuable to everyone who is trying it. 


    • chipur August 2, 2011, 5:42 pm

      I know you’re struggling, Molly. And the fact that you continue to post, and try to help others, is inspiring. Thank You…


    • vibrant August 2, 2011, 7:43 pm

      hi molly – i’m with you.  i think i’m more anxious on this drug.  and funny that bill just posted an article on catastrophizing.  i rarely have done that in the past and all of a sudden, i’m doing it!  WTH?  
      don’t think i’ve had palps, but this drug definitely amps me up and keeps me awake at night.   i feel like my dr. really is pushing me to stay on it, but at the end of the day, it’s my body and if i don’t feel better on it soon i’m going off.   if the dr. doesn’t like that, then i’ll find a new doc.  

  • Elbabes_06 August 2, 2011, 6:22 pm

    I am wondering how long it stays in your system after stopping use. I stopped after my 2nd day on the 20 and it’s probably been a week or so that I haven’t taken it but still am not feeling how I felt before taking it and get times where I see sparkly spots and my anxiety is higher than normal even when taking my clonopin which used to ALWAYS help…

    • Rockie August 5, 2011, 7:44 pm

      I stopped after three weeks on 10mg — tried going up to 20mg but couldn’t tolerate the SE’s — and am still having SE’s and/or discontinuation symptoms after over a week. It does seem like they’re slowly dissipating, but I’m still experiencing GI issues and excessive sweating.

      In terms of SE’s when taking the med, I got them all. Here’s the short list:
      – Increased anxiety
      – Decreased mood
      – Gas/bloating
      – Nausea
      – BM issues (use your imagination)
      – Increased sweating and night sweats
      – Muscle weakness
      – Low energy
      – Low motivation
      – Disturbed sleep pattern (sleeping 3-4 hours a night)
      – Headache

      • Rockie August 5, 2011, 7:57 pm

        Forgot to mention that I didn’t notice any sexual SE’s at 10mg, but experienced anorgasmia at 20mg. Wasn’t at 20mg long enough to see if it would go away. Also, I did gain a few pounds while I was on it, but I’m attributing the weight gain to my Lamictal and Neurontin.

  • Katherine August 2, 2011, 9:38 pm

    Hello, I’m going to be starting viibryd in a few days my dr. is starting me on 10mg I’m looking forward to hopefully getting my life back under control plus I’m a little worried on how this new med is going to work I’ve been on wellbutrin for so long its was only helping part of the time and my dr. said thats not good enough so he suggested this one I’ll let ya know how it goes… keep your fingers crossed for me

    • chipur August 3, 2011, 5:39 pm

      Fingers and toes are crossed. Katherine, thank you for your visit and participation. Please share your experiences with us, okay? We’ll be here!


      • Carole terwilliger August 12, 2011, 5:29 am


      • chipur August 12, 2011, 3:34 pm

        Thank you for your visit and contribution, Carole. And thanks for the kind words. I will for sure keep up the good work!

        I admire your consideration for your family – putting off starting a new med until after their visit. And let’s face it, it’ll allow you to better enjoy their stay. Time with our children is priceless, especially as they (and we) get older.

        By the way, will be a first time granddad (supposedly) Sept 6.

        I’m very sorry to read that you’re having to turn to meds to somehow cope with your husband’s behavior. As you said, I’m sure you do all you can to walk away; however, we’re all human – and that’s tough to do time and again.

        Keep coming back, Carole. Your participation is valuable to everyone!!!

  • chipur August 3, 2011, 8:53 pm
  • Mam0355 August 4, 2011, 2:24 am

    Hi all,

    I haven’t posted in quite awhile.  I am done with my starter pack of viibryd and just picked up my 40mg prescription today.  I can’t say I’ve had dramatic results, nor many side effects. The main side effect seems to be frequent red and blurry eyes.  

    I was hoping that viibryd would make me want to jump out of bed in the morning ready to take on the day. I can’t say that has happened.  Somedays I take a 10mg adderall for some energy and focus.

    I have to admit that I have not given up my two glasses of wine every night.  After reading some of these posts, I am thinking that the alcohol could be working against the potential benefits of viibryd.  I also occasionally take a percocet for pain and wondering if that is also counter-acting the viibryd.

    I am going to really try and cut out the wine and see if I start getting better results.  Thanks to all of you for your valuable input.  We are all in this together and sharing our individual experiences is so valuable.

    Thanks Bill for starting this forum.

    • Mam0355 August 4, 2011, 2:26 am

      I am not sure why this posted as Mam0355.  I had previously posted as MedQueen.  Just FYI

    • chipur August 4, 2011, 4:40 pm

      Hey! Hey! My pleasure. I’ll be curious to see what happens when (if) you cut out the wine. I’m not saying I believe that will make a huge diff, but let’s see. Dial us in, okay?


  • Miss CC August 4, 2011, 4:52 am

    Im reading all of the posts and am concerned about some of the palpitations people are having…. thats scary. I would def call your doctor about that. I too was like some of you that were SO excited to start this drug thinking it would help a lot….its been two weeks and ive only been on the 20 mg for about a week so I am hoping it gets better….

    Is anyone else experiencing an increase or decrease in hunger? I know I could just be feeling better so my appetite is increasing but it scares me as I am TERRIFIED of gaining weight…

    Best of luck to everyone. Stay strong :)

    • chipur August 4, 2011, 4:44 pm

      You stay strong, as well!!! I’m glad you’re continuing to post…


    • Bprescott61 August 5, 2011, 12:25 pm

      yes yes yes on all of the awfu side effects above!!  the awul anxiety, sleeplessness, gi,… i am so disappointed adn feel lots of pressure to stay on it. 

    • vibrant August 7, 2011, 9:44 pm

      hi – yes an increase in hunger at first, but it seems to be leveling out for me .  i’m on 20 mg and going to stay on that for a while.  on the positive side – i have  A LOT more energy to get up and do stuff on this drug – so if i happen to eat a bit more, i know i’m burning more calories because i’m more active.  this drug doesn’t let me sit still!  squirmy!  the tingling in hands and feet are lessening.  having very vivid dreams (usually positive dreams though).  still experiencing insomnia.  dr. gave me something to sleep till i adjust to the drug.  (don’t like that – but i’m trying to stick it out) i’ve never really had problems with insomnia so this is weird for me.  i stay up really late 11 – 12 am now – before, i’d be asleep by 9pm!    

      • Miss CC August 9, 2011, 4:14 pm

        Thanks for your response! Thats so weird everyone seems to be having issues with insomnia..NO JOKE I have been had such a regular sleep pattern since being on this drug. Its great. I dont know if its the drug or just my body but its odd. Im on my 4th day of the 40mg and I think it might be too much. I started getting really dizzy and kind of “spaced out”. Im trying to stick it out with the 40’s to see if it’ll get better. Your right, as far as the appetite thing it seems to be leveling out. I too have more energy to get things done. Have you tried taking an OTC sleep aide to help with your insomnia? That always helps me… Oh yes one more sideeffect I’m having. Restless legs, it was only really bad for a day or two and now its gone but WOW, that was annoying…..

        God bless

      • vibrant August 16, 2011, 9:04 pm

        hi miss CC – yes, the restless leg thing was awful!  but it’s gone now as is the tingling in hands and feet.  i’m taking OTC meds and melatonin for insomnia.  hopefully it will level out along with everything else.   glad you’re able to sleep -that’s great!  i was on 40mg for about 3 weeks and it seemed too much for me – the restless legs and insomnia were much worse.  i’m on 20 and will stay at this dose for a while i think.  yes, hopefully our extra energy will burn calories!  best, v

      • Leilani August 10, 2011, 12:39 pm

        I’m not “glad” but I’m glad you posted that you have been having insomnia! Mine has been the exact same way!!! I usually go to bed at 9 and am out. Now at 11 I’m literally forcing myself to bed to at least relax because I’m so awake! I’ll maybe sleep for an hour then I’m awake for an hour, this continues on throughout the night. The weirdest part is when I’m asleep… It’s like I’m still awake but dreaming. Very strange. I’m so tired but at the same time not tired at all. I was taking sleep aids (lunesta) every night for the first week of the 40mg decided I wanted to try a week without them and haven’t slept in 5 days. Will this go away!?!?! Is it transient!?!?! I like having more energy during the day but I need sleep!!! Help!?!?! I don’t want to go back Prozac where sexual side effects, no emotions and lack of motivation rule. :( So if there is anyone out there that can give hope that the insomnia will go away and I won’t have to depend on lunesta for the life of this med… Please give us insomniacs hope to keep pushing on! Thanks

      • vibrant August 16, 2011, 9:10 pm

        hi leilani – i think your description is spot on – tired, but not tired at all.  this drug doesn’t seem to let my body rest, but it doesn’t seem to bother me.  it’s really weird.   – yes, awake but dreaming.  i’ve been taking OTC sleep aids every night too!  i have never had insomnia in my life, and i’m waking usually at least twice in the night – at almost the EXACT same time every night which is bizarre.  (always 2:15am!)  i feel like it’s a trade off – having extra energy i never had while i was on paxil.  i have motivation and energy i’ve never had.  (thought it was kind of manic in the beginning, but it leveled out and now seems more normal..)  yes, i would like to hear if the insomnia has left anyone else yet too….anybody?   hope it just levels out like the rest of the symptoms.  best, v.

  • chipur August 5, 2011, 6:44 pm

    Calling all chipur readers! Wanna’ get better? I’ll teach you, okay? Here’s a piece I just posted on cognitive distortions.

  • Thegman509 August 5, 2011, 10:28 pm

    well i decided after 5 weeks and wierd side effects and my anxiety and panic attacks going up viibryd isnt for me, thats not to say it wont help millions, i hate when people only put the negatives of medicince so if your new on it give it a real try dont focuss on the bad hope it works for you, remmember opinions are like a$$holes every one has one

    • chipur August 6, 2011, 7:13 pm

      Thank you gman. What more could I possibly say???

  • lkelley36 August 5, 2011, 11:48 pm

    Hi all!! Gosh, I am so sorry that some of you have experienced some awful stuff!! That just proves that some meds are for some and some are not!! Being a hypothyroid patient, I am always worried about weight gain…have not had that at all! I guess I am one of those that have not had any, for the most part problems. No GI…a little heartburn, a little more going to the bathroom…but, I have been on 4 anitbiotics for an abcess tooth…So guess that isn’t the V!! I have said before…the first 3 or 4 days in the 20’s and then the 40;s were a little strange….I felt as I were walking on a cloud…but man, I may be a little gunho, but I love this med so far!!! I won’t get into my life and why….but to be laughing and crying, at the right times is awesome!!!

    • chipur August 6, 2011, 7:16 pm

      Amazing how so many take the simple things (like laughing and crying appropriately) for granted. Be sad and happy at your leisure – and enjoy them!!!

  • Crazycatgirl August 8, 2011, 9:35 pm

    So today Im on day 7 of the 10mg, started taking it more towards lunch time than at night, and thus far I have a headache and same ol stomach issues, Have no desire for food at all, and loosing weight! Over all if the headaches subside and the bubbly tummy subside, I can deal with this as i am seeing light for a new life for me at the end of the tunnel, however tomorrow i start the 20 mg and im kind of nervous!

  • brittanybrox August 8, 2011, 10:42 pm

     I have been reading this thread for a little bit now and finally have the nerve to post. This is my second day on the 10mg sample pack. I have’nt noticed any side effects or any effects yet… Still have a lot of hope though! It’s a little scary because I also have epilepsy and Viibryd has a big seizure precaution. I’ve been seizure free for almost 3 years so my neuro okay’d it, he was actually the one to prescribe it. Most likey because I begged.  I’m also on 400mg Zonegran, 1000mg Keppra, and 1mg Ativan. I know, a lot. To top it off I drink more than I should. Diagnosed with MDD. I was on Paxhell and it did elevate my mood but destroyed my libido. It was to the point where I stopped taking Paxil cold turkey, priorities;) Definitely, a mistake..
    I’ll keep posted. Thanks Bill for starting this!

    • chipur August 9, 2011, 6:43 pm

      Hi BB…

      “…finally have the nerve to post.” Well, see, it was painless, wasn’t it. Yes, be sure to keep us posted. And you’re welcome…


    • vibrant August 16, 2011, 9:19 pm

      hi brittanybrox – i was on paxhell for over 10 years.   good grief the w/d coming off was horrible.  glad you pulled thru too.  this drug has a very different effect on me.  much more energy, able to have emotions (crying – never cried on paxhell).  you have a lot on your plate for sure.  i hope this med helps you.  i have a child with autism and epilepsy, so i know some about that…best. v.

      • chipur August 17, 2011, 1:09 am

        “Paxhell” I love it. Took it many moons ago…

  • Jack August 8, 2011, 11:55 pm

    Hey! I appreciate this site being here and all the comments. I’m a 54 year old male on day 5 and things are OK. Nothing too dramatic to report here, no significant changes yet.  Because of ALL the input here I have hope and am encouraged to stick it out if/when things get weird.

    • chipur August 9, 2011, 6:50 pm

      Hi Jack…

      Welcome! Glad you decided to visit and participate. There’s every reason to be hopeful and encouraged. Continue reporting, okay?


  • Boo-a-roo August 9, 2011, 1:30 am

    I made it up to the first day of the 40mg before I decided being depressed was the lessor of the two evils.  Side effects included insomnia (waking at 3am every day), frequent urination, twitchy feet and crawly skin, extreme mental fog, fatigue, lack of interest in anything, basically a depression on top of the depression.  Going back to the doc to see what else might work.  I need my energy and joy for life back.

    • Boo-a-roo August 9, 2011, 1:34 am

      Add anxiety to that.

    • chipur August 9, 2011, 6:55 pm

      Sounds like a well informed decision, Boo-a-roo. Guess there are some things worse than depression…

  • Mama1p August 9, 2011, 1:45 am

    Thanks to all of you for sharing your experiences.  Called my Dr and told him I was unsure about starting Viibryd, do to start 8/14.  He said hold off until we talk face to face.  Like all of you, they are also learning. 

    Bill…thank you for starting this, sharing is caring, and that is what we are doing here.

    • chipur August 9, 2011, 6:56 pm


  • Leilani August 10, 2011, 12:41 pm

    Oh one more comment…. (i just left the help to insomniacs below) For those who have discontinued this med…. Any withdrawal symptoms or was it a pretty clean break?

    • Mama1p August 10, 2011, 6:36 pm


      Did you discontinue Viibrdy and if so why?

      • Leilani August 10, 2011, 10:33 pm

        I did not discontinue Viibryd. I have a pill cutter and am going to start cutting the pills in half. I actually love the drug! It makes me happy but still with normal emotions, I have sexual feeling/desire, Im less edgy and it gives me energy and motivation. I feel good and normal, my only issue is the insomnia, and from what I know it should go away. I hope that it does. I am going to stick it out bc it typically takes an antidepressant 8 or more weeks (I’ve been on it for about 4) to have true results and by then if the insomnia does not go away… I guess I will have to weigh the pros and cons of either stopping it and switching back to Prozac :( or taking luniest more often. I was just curious if anyone had withdrawal symptoms bc I know some antidepressants have them and you have to taper off very slow. The package insert doesnt say. hope that helps.

        I wouldn’t be worried about giving it a real try, at min 4-6 weeks. It may really help you. There are so many different antidepressants out there and they work differently on everyone. That is why it is tough to say exactly how you will feel…. I may have insomnia where some one that commented earlier said that they sleep too much on it. I have had no diarrhea where others have had it.. It is all trial and error. If this makes you feel better there was also a 52 week safety study done and the drug proved to be safe and effective. :) good luck to you! If you are really nervous, taper up slower then normal, it will take longer to see results but there will potentially be less side effects. Ask your doctor they should help.

      • Mama1p August 10, 2011, 11:53 pm

        thanks for your support.   I have tried it all and nothing works and when it does it is only for a short time.  Found one that was great but when I kneeled, I couldn’t get up, it was weakening my muscles.  My Dr is wonderful, we will talk next week and figure out what to do.  I have to take care of my sick husband so side effects are major concerns,

      • chipur August 11, 2011, 2:07 pm

        Well written, Leilani. Thank You!

      • chipur August 11, 2011, 2:05 pm

        I doubt it. But may have discontinued Viibryd ;) (couldn’t resist). Hey, maybe “Viibrdy” could be our word for that spacey feeling many of you chat about…

  • Mama1p August 10, 2011, 10:14 pm

    Those of you that cut your pill in half, what did you use to do it.  A friend of mine is also on Viibryd and needs to cut her sample pack pills in half per Dr. orders

    Hang in there…it got to get better.

  • chipur August 11, 2011, 1:52 pm
  • chipur August 11, 2011, 3:22 pm

    Hey chipur readers!

    I want to share a comment, and my reply, from my article “I Can’t Take It Anymore!” (10 “Yes you can’s”) It’s that important…

    From reading many of your articles, I get the feeling that deep down you believe that the majority of people on anti- depressants could actually do without them. I know you’re not referring to people with diagnosed conditions, like bipolarism or schizophrenia, but those of us who feel or have been told by our doctors, that we need extra help in pill form. I think very highly of you and all the effort you put into helping people. I’m also considering consulting you for therapy. But I am curious if I am misunderstanding your true feelings about medications.

    Ding! Ding! Ding! Great catch, comment, and question. And I’m going to give it its due…

    First of all, as a lifelong anxiety and anxiety-associated mood disorder veteran – and clinician – I am not anti-med.

    After finally being diagnosed in 1989, I started on imipramine (Tofranil) – a tricyclic antidepressant (TCA). My life drastically changed for the better. ‘Course, I had plenty of work to do on the social front – and therapy helped a ton. Retrospectively, imipramine alone would not have brought me to where I am today.

    When the SSRIs became popular I switched to paroxetine (Paxil), and went to sertraline (Zoloft) several years later. You can toss in clonazepam (Klonopin) on occasion. Heck, in the midst of an acute phase, a psychiatrist tossed risperidone (Risperdal) my way. That ended after two doses. Yikes!

    I left Klonopin behind several years ago, and stopped Zoloft (100mg) some two months ago. I’ve had no return of symptoms, nor do I expect an encore.

    That said, before turning to Paxil years ago, I stopped imipramine because I was feeling great. I thought I’d reached the promised land, but several weeks later I plummeted. Hence, the call of desperation to my psychiatrist.

    Meds definitely have their place in the treatment of any of the emotional/mental health disorders. And I would never be judgmental re their use by a client, family member, friend – or me.

    Do I believe meds are often relied upon too much? Yes. Is it my (and chipur’s) philosophy to gently make such a statement when and where appropriate? Yes. Do I know it’s a delicate issue? Absolutely.

    I wrote my first article on a new antidepressant, Viibryd, back in March. I had no idea that what I’d written would become so popular. I spend hours throughout the day/evening/overnight keeping current with comments, emails, the forum, and newsletter thank yous – and I love it!

    But I do find it curious that the other pieces I’ve written, detailing some very strong/proven relief strategies and techniques, just don’t get the traffic and comments? Yes. And I typically provide notice of a new article in the comment section of the two most popular Viibryd articles. I’m no marketing guru, but I ain’t the dullest knife in the drawer either.

    My major concern is readers may not be enjoying the benefits of a full treatment protocol. Hey, meds are huge – I know that. I mean, I can recall being housebound in the early/mid 80s because of agoraphobia. And I can recall long stretches of derealization, depersonalization, intrusive thoughts, and more – having no idea what they were. I just figured I was going mad, and that was going to be that.

    I know what it feels like to be sick beyond hope and so desperate I’d devote all my attention to the quickest and supposedly surest fix. But over time, I learned the value of other treatment strategies and techniques – including moving forward like a zombie until I somehow made sense of, and peace with, my world in the immediate.

    I hurt with anyone who shares a painful comment on chipur. And it hurts to know he or she is spending to the max in terms of personal resources to make a med work – and make another one work when that one stops.

    I just want to make sure all bases are being covered. And for all I know, they are.

    Dang! Didn’t meant to go on that long, but you hit a nerve – and I’m really glad you did.

    My life wouldn’t be near as full and fulfilling without chipur and its readers. You have my ongoing empathy and respect. Always!


  • Ruca August 12, 2011, 10:14 pm

    Haven’t checked in with you guys in a couple weeks. I am about a month in and after trying the 20mg, I talked to my dr and he told me I could stay on the 10mg. I feel really leveled out and ‘normal’ on the 10mg.

    My dr made the mistake of telling me to take my pill at night…so that was what was causing my insomnia. I now take it in the morning after breakfast, and can sleep all through the night. It’s wonderful. 

    The only annoying side effect I’m having is the sensation of hunger that I deal with as soon as I take the pill. It lasts all the way until I go to sleep. It’s almost like a heartburn or indigestion feeling. So..I munch and snack…get physically full and still have the hunger feel. It’s really annoying. 

    other than that…the 10mg have really managed my irrational thoughts, they pass quicker and I’m able to be in a happier mood and more social.

    so far it is the best medication I’ve been on. I’ve also stopped taking my clonazepam thanks to Viibryd.

    • chipur August 13, 2011, 1:16 am

      Excellent report. Good for you, Ruca. And, hey, if it wipes out the benzo – all the better…


  • chipur August 12, 2011, 11:09 pm
  • Mama1p August 13, 2011, 3:21 pm

    Did anyone start Viibryd without coming off another med at the same time?  Also, is anyone one taking V with no other meds?  If so, I would love to know what side effects you are experiencing  or did experience.  Right now I am on nothing (on my last day of washing out the MAOI) and we aren’t planning on adding anything if we decide to start V.  I believe the more info I have when I walk into his office the better prepared WE will be to make decisions.  thanks to all of you for sharing  what you are feeling.  I believe that by sharing with others who understand what you are going thru is a very postive thing.  One less thing to  bother us. 
     Wish I knew about this site 4 years old when I had a mental breakdown and had to have 12 ECTs.  Couldn’t find much info about  ECT then.  Also, to talk to people who understood what I was going thru was hard.  I did go thru out patient hospital therapy, it was alright, but no one was there for MDD, so even they couldn’t understand fully. 
    Please, all of you keep us updated, we can never have to much info especially when it comes to new meds.

    Just stay positive…I know it is easy to say then to do, but we are stronger then we think.

    • chipur August 13, 2011, 5:47 pm

      Thanks for your detailed comment, Mamm1p. I’m glad we could be here for you. chipur readers – here’s a link to the first in a series I did on ECT. Fascinating stuff.

    • Ruca August 19, 2011, 9:50 pm

      I am not taking anything else nor did I come off of anything else. 

      I am a couple months in on 10mg and am just experiencing the urge to eat/hunger tummy rumbles. I got over the insomnia and any stomach issues. I just literally feel like I want to eat all the time. 

      It is the best medication I’ve tried for my anxiety/depression. I don’t feel medicated and I am able to deal with life and situations that would usually throw me for a loop. 

      I love this medication. 

      • chipur August 20, 2011, 1:07 am

        Nice report, Ruca. I’m glad things are working out for you.

        How are you coping with the “hungrys?” May help others…

  • mb August 14, 2011, 8:13 pm

    I was given sample packs of the Viibryd, the pack began with pills of 10mg which progressed into the 20mg, followed by the 40mgs; when starting the antidepressant they have you step up your dosage every 10 days until you hit the 40mg, except the first three 10mg pills are to be cut in half so you start at 5mg.  My response to this medicine was near polar opposite of what my Dr had said. 
    This medicine made living day to day comparable to a rollercoaster; unjustifiable crying spells would hit me at any point, anger and depression were amplified and my feeling of self worth was more that of being a burden to everyone around me. Sleep loss did occur, as did lowering of sexual drive, appetite and thoughts of suicide. My symptoms have never been this extreme and it was a very frightening the lonely experience; co-workers and friends were starting to voice concern, where they had none before. I was on the medication for a few months, as well as having the DR add ANOTHER prescription to help amplify the Viibryd; after adding the booster similar to Abilify and having the symptoms worsen yet again,  I decided living with this medication was not going to be a likely scenario, as well as the Dr not working for me; if you can’t listen to your patients as they tell you they are rapidly just getting worse, you shouldn’t be in the field. I’ve been off the medication for a few weeks and have been feeling more like myself as time goes by. However, I will admit my underlying depression is still present, but WITHOUT adding that “miracle pill- Viibryd” it is easier to keep under control, and has made social situations and interactions possible again.


    • chipur August 15, 2011, 12:35 am

      Hi MB…

      I appreciate and respect what you had to say. Viibryd isn’t for everyone. And I’ll tell you this much, whoever refers to it as a “miracle pill” really needs to be careful. Certainly within the prescription drug world there are such pills, but I can think of precious few psychotropics. And the ones I’m thinking of still have major down sides. Kind of sad, don’t you think?

      Thank you for your visit and comment…


  • chipur August 14, 2011, 8:33 pm

    chipur readers! Here’s the article on rebound effect I promised several days ago.

    • LSM August 14, 2011, 10:02 pm

      Oh man. I have been taking Viibryd for about two weeks. Although it does help with depression and crankiness (and no sexual side affects), the last week ive woken up with a slight headache, queasy stomach, and feeling like I just need to lay down to keep from feeling worse. At first I thought I was just coming down with something or I was not eating healthy enough , but I am pretty sure now it is the Viibryd . I am not taking it anymore as of today and I hope this goes away, because I feel HORRIBLE! I really don’t like the blah feeling i got with luvox (the feeling where nothing makes you too sad, but nothing makes you really happy either), but i dont know what other choice I have , Viibryd definitely aint it!

      • chipur August 15, 2011, 12:40 am

        Hi LSM!

        Well, another Viibryd user bites the dust. “Oh man.” What more can you say? Comment noted, and I sure appreciate your visit and participation.

        Please come back and comment on some of the other articles here on chipur…


      • LSM August 15, 2011, 6:52 pm

        Lol, thanks for the kind words. I may have gone of off my Luvox too quickly and upped my dose of Viibryd too quickly, so I will still stick around and see what others are experiencing, maybe in the future Ill try it again but convert more slowly and see if that helps. Now that I have been off it for over a day, I am starting to feel better. But I also took a luvox, so im not sure if i was having withdrawals of luvox or nasty affects from viibryd, although Im pretty sure its the latter…

  • ls August 14, 2011, 10:29 pm

    Hi LSM,

    I had/have that too when I wake up from crazy dreams…not bad dreams…just dreaming…having that awful feeling in the morning, but after taking my V…it seems to get much better…really Wow better! It is the only bad side effect that I have had. I just have worked through some of the dizziness and stuff. Sorry you have had a hard time, but I will say, you have to get it into your system before things are working correctly. My doc said to give it 20 days…and after that weird up to 40mg…I am soooo loving this med. I had that blah feeling with Lexapro years ago when I took it. I hated that feeling. When I asked the doc about something other than that, she gave me V. Hope everything works out for you!! Seems this just is great for some and awful for others, or in some instances,…just nothing to some. Wonder why? Strange!!

    • chipur August 15, 2011, 12:43 am

      And that’s what happens when one manipulates brain physiology. Hey, for some it’s amazingly helpful. For others, a bomb…

    • LSM August 15, 2011, 6:54 pm

      Thanks LKelley, Im going to give it some time and maybe in a month or so try again, this time getting off the luvox more slowly and upping the viibryd more quickly. I really want to give it another chance, we will see. Im glad its going so well for you, comments like yours give me the courage to try again in the future

  • Lola August 16, 2011, 5:16 pm

    I am on Day 1 of 10 mg.  I am very scared whenever I try a new medication; but the dr. told me to give it at least 3 weeks.  I have had anxiety and depression since the late 80’s.  Have been on the gamut of all types of medications, most recently Prozac.  I found Prozac generic did not work for me so I switched to brand.  However after having Prozac level off, I began again to experience anxiety (my biggest problem).  I am terrified of the panic attacks.  I tried Lexapro and did very well on it but the dr. took me off of it due to weight gain.  I also took a week vacation because I was scared as to the side effects I may experience and didn’t want to deal with it at work.

    I am to take the doses in the morning with food and in the evening 1mg of klonopin to help with the anxiety. Although I find that xanax gives me immediate relief from any anxiety she is completely against my taking that.

    I’m very scared and after reading some of the posts am terrified but I will stick it out as I have done before.  So far mid day of day 1 I feel ok.  I have had some diahrrea but that is not uncommon for me since I had my gall bladder removed.  Hope to continue to see positive postings on this medication and thank you Chipur for having this forum available.

    • chipur August 16, 2011, 8:30 pm

      Hi Lola! Welcome to chipur and thank you for participating.

      You know, I remember when I was an anxiety newbie filling my first scrip. It was a benzo, but I don’t remember the name. I got it filled, but was so scared of taking it – that I never did. BUT, I kept it in my pocket at all times just in case. We’re funny folks, aren’t we?

      Don’t know if you caught it, but just scanning your post you made reference to fear five times. Hey, you’re gonna’ be fine, okay? And that comes from a guy who was housebound with agoraphobia some 25 years ago.

      Stick around, okay? We could use your participation – and it sounds like you could use the support.

      You’re more than welcome…


  • RJ August 16, 2011, 6:30 pm

    I am on day one…  I am concerned that this forum is ONLY posting negative comments… It has made me somewhat scared.  Do you think everyone is having problems, or that the people that it is helping and have little or no side effect just don’t post here

    • chipur August 16, 2011, 8:36 pm

      Oh, I don’t know, RJ – there have been some nice results posted here. And be sure to catch the update article

      Do all you can to go into your experience with an open mind, okay? Heck, you may even want to stay off the forums (did I just say that?) for the first few days. I’m assuming you’re starting at 10mg. You’re gonna’ be fine, RJ. Come on back and share – and grab some support…


      • LSM August 17, 2011, 3:21 pm

        This may not necessarily be the case, but keep in mind that people usually tend to seek out forums and discussions more when they are having a negative experience, since they need help or answers, so that may explain the fact that there are more negative comments than positive. At the end of the day you should base your decision on what your doctor says and on your own experiences. Unfortunately with new medicines like this, you won’t really know till you try…

      • chipur August 17, 2011, 5:19 pm

        Hi LSM…

        I can buy that. Underscoring, “At the end of the day you should base your decision on what your doctor says and on your own experiences.”


  • chipur August 18, 2011, 12:34 am

    Just posted new article on the cognitive distortion overgeneralization. See if you do it!

  • InRecovery August 19, 2011, 3:55 pm

    I was just given a Months sample pack of Viibryd by my doctor. Now keep in mind that im on suboxone to kik Heroin and on 1 mg of Klonopin for Anxiety and for insomnia (which im sure are related). i have been on several SSRIs Paxil, Celexa, Lexapro, Most recently Prozac. Ive had the most relief of Anxiety and depression from the Lexapro but its to exspensive so went to prozac which didnt seem to do much 1 way or the other. My main question is i have had seizures in my life and in reading the warnings i see #4 is about Seizures. Just curious if anyones seizures have been aggrivated by the Viibryd and if all think its safe to take i can deal with GI probs and bein tired but i already have insomnia and do not want more of that and i definatly do not want a recurrence of seizures. I also have Liver Problems (Hep C Specifically and of course it was from the Heroin useage *cough* Needles are bad) so that may be another reason im being careful. Just curious what u think and  any advice is appreciated.

    • chipur August 19, 2011, 6:56 pm

      Hi IR…

      First of all, thank you for visiting chipur and participating. Not only will you find some help by posting, others will, as well.

      Man! Regarding Viibryd and seizures – here’s the specifics from the prescribing information…

      “Seizures: Can occur with treatment. Use with caution in patients with a seizure disorder (5.3).
      5.3 Seizures
      VIIBRYD has not been systematically evaluated in patients with a seizure disorder. Patients with a history of seizures were excluded from clinical studies. Like other antidepressants,VIIBRYD should be prescribed with caution in patients with a seizure disorder.”

      So it isn’t so much that the Viibryd brain trust knows from the trials the med can induce seizures – it’s a matter of not knowing. And that’s because they excluded seizure disorder patients from the trials.

      Hey, IR, I’m going to have to yield to your doc and chipur readers on this one. I mean, if you’ve taken SSRIs before and have had no issues, I’m thinking all is good. But then there’s the 5-HT1A receptor partial agonist action of Viibryd. Is that a difference maker? Could be?

      Keep stopping by, okay???


  • KYNanny August 19, 2011, 4:54 pm

    Was given a 1mo. pkt of Viibryd a couple days ago by my psych for my OCD and anxiety and other phobia issues. Will be starting it this weekend since I’m so sensitive to meds. Tried Luvox (I think) and wound up extremely angry over anything and everything, so, that got kicked to the curb. I came to this site yesterday and read everyone’s comments yesterday. I read about someone complaining that there’s just negative responses. I read some positive and truly appreciate the good w/the bad. Being so hypersensitive to meds since turning 40 (a dozen years ago), I’ve started to expect the worst out of meds from the get-go. I read and re-read side effects before I even start a new med so I know what to expect from the meds. I’ve had anxiety/OCD/phobia issues for “forever” and am just now starting to deal w/them. I realize the anxiety and phobia issues are all in my head, but, I’m tired of just “dealing w/it” or “trying to think of something else” as my mother and husband always suggest. Too bad it doesn’t work that way. Add to the mess some ADHD too. What a mess! LOL! I appreciate everyone’s comments and complaints about the meds. I’m trying to be optimistic about the meds, but, I’m just too much of a pessimist. I’m okay w/that though. I’m already expecting the GI issues and am hoping they’re not TOO bad or that they go away after awhile. I figure by starting the meds over the weekend, I hope to get the harshest reactions either out of the way or find a way to subdue them somewhat before heading back to work on Monday. Good luck to all of you that are still on the med and those who’ve kicked it to the curb. I’ll keep you posted next week. Fingers crossed! Have a wonderful weekend everyone!

    • chipur August 19, 2011, 7:05 pm

      Hiya, KYNanny! Sure glad you stopped by chipur and decided to contribute.

      Ah, were it as easy as “dealing with it” or “trying to think of something else.” I’m “thinking” most everyone here knows that – hence, you’ll find this a comfortable place to share and learn.

      Good idea, getting things cranked-up over the weekend. I mean, hopefully it won’t have been necessary, but it’s wise to play it safe.

      I’ll for sure look forward to your future posts. The perspective of one who’s taking Viibryd for anxiety issues will be valuable.

      Great hearing from you…


  • chipur August 20, 2011, 1:57 pm

    Hey chipur readers! On the way to Chicago – will touch base this evening…

  • so far so good August 21, 2011, 2:14 am

    Hello everyone,
    I’ve never commented before. I’ve been on Viibryd for about a month now. I was really reluctant to take it at first because it was new and haven’t had good experiences with anti depressants in the past. I’ve taken Celexa, Prozac and Wellbutrin in the past and they all made me feel numb. Wellbutrin especially made me feel horrible and suicidal. So I wasn’t sure what to expect. The first time I took Viibryd I remember being so nauseous I threw up and felt sick the rest of the day. I had bad diarrhea and just felt really tired but couldn’t sleep. For the next week that I took it I had this weird urge to run. Like all I could think about was that i needed to run a mile or something. It was bizarre. It made my legs really restless too. I’d just lay awake in bed extremely exhausted but not being able to sleep. It also made me sweat hard. I probably looked insane because i was drenched in sweat everywhere i went. People probably assumed I was a rapist, a sweaty one. I’d also feel as though I was in a fog, and not totally there. Just like an apathetic doped up zombie. And that was alright. But it didn’t really let me think at all or even really put together basic sentences. I was still falling back into depression and having anxiety and mood swings etc.

    Sorry I’m digressing I’m just trying to compound my whole months experience into this one post. So long story short, I now feel really good. I don’t feel doped up or in a fog anymore. I can sleep now no problem (i do get kind of sleepy right after taking my pill though so it might be better to take it at night) I feel like me, but only a calmer, happier, more rational version of me. I don’t feel like I’m on any medication. I just feel okay with things. I’ll just be happy for no reason. One complaint. I have no sex drive whatsoever. I thought this pill was supposed to help with that? I haven’t gained weight but I have zero interest in sex, like i can take it or leave it. Bust mostly just leave it. Other than that i feel like i can do things on my own and yeah things still suck but i don’t feel overwhelmed by them anymore. I feel like I can handle it. I just feel content. It’s a good feeling. This is a great antidepressant, but I understand it’s not for everyone. It’s still pretty new so I worry about the long term effects it might have. Anyway I’ll update again if anyones interested

    • chipur August 21, 2011, 4:12 pm

      Hi sfsg (ya’ like that?)…

      I sure appreciate your chipur visit, and the contribution is excellent. Glad you decided to go ahead and post.

      Good reading you’re doing well on V. Yeah, the sexual thing. Well, I wouldn’t be surprised if it turned around in fairly short order. Remember how horrible you felt when you first took V.

      Of course we’re interested! So, please, keep us posted…


    • Vibrant August 27, 2011, 10:23 pm

      hi – i’m with you with the sex drive thing.  i’ve been on 20 mg for about 2 months.   it was a rough start – like you i had the restless legs, tired but not able to rest, and more sweating for me too.  anyhoo, i’m feeling pretty take it or leave it too.  i thought this was going to be a wonder drug in that arena.  but other people are saying it hasn’t affected them in this area so it must be different for everyone.  i’m feeling pretty good myself on this stuff.  i was ready to quit several times, but stuck it out.  i have soooo much energy on this drug.  i still feel emotions – i cry, get angry, sad – i was a long time paxil user and that drug ‘flattened’ everything (the joy too).  only thing with me is that i still have insomnia and i think i may be a bit irritable on this stuff at times.  but for now, i think i’m going to stick with it.  

  • chipur August 21, 2011, 3:37 am

    Loooong travel day, chipur readers. I’ll check-in Sunday morning…

  • Mhtrainers3838 August 21, 2011, 11:58 am

    tried to reply to a post here that was written a couple weeks ago,,i cldnt pass the verification,lol may need more adderal,lol

    • chipur August 21, 2011, 4:26 pm

      Keep trying, mht. And I’ll bet you can do it without the A!!!


  • chipur August 22, 2011, 2:29 pm

    Heading back to Detroit today, so it’s travel time. I’ll catch up this evening…

  • Ebbers48 August 23, 2011, 5:40 pm

    Anyone?  Does it exacerbate RLS?  This is a major problem for me with anti-depressants and the Wellbutrin is not working for me. I am either angry or sad.

    • chipur August 23, 2011, 7:37 pm

      Hi Ebbers48…

      I’ll look to chipur readers to comment on RLS and V. I mean, it’s one of those psychotropic meds things – there certainly isn’t an official warning of such; however, it could pop up for some folks. But you gotta’ remember, even if someone reports it, that doesn’t mean it’ll happen to you.

      Thank you for your visit and contribution. Please keep it up!


  • Star August 23, 2011, 11:02 pm

    I started the 10mg today and felt groggy, nauseous, gastrointestinal discomfort, and super dizzy shortly after ingesting the pill so reading this forum was insightful knowing others have had the same experience. Thanks for creating this forum. I’ll definitely check back again!

    • chipur August 24, 2011, 12:23 am

      Other than that, everything was just fine – right?

      Thank you for visiting chipur and for “chippin'” (I couldn’t resist) in. Each and every contribution is valuable. Glad we could be of assistance regarding what I’m sure were some icky side effects.

      Be sure to come back for support and sharing, okay?


  • chipur August 24, 2011, 7:30 pm

    What if I told you exercise brought remission to 30% of those who were experiencing a stubborn depression? It’s true! Just posted an article with the supporting research.

  • chipur August 26, 2011, 1:27 am

    Important Heads-Up!!!

    In a few days I’m going to close comments on this article. Here’s why.
    The response has been incredibly heartening. But I’m getting reports of
    slow page loading – even problems with typing a post.

    The best solution is to transfer the chat to the chipur forum. And you
    know what? You’ll find it easier to work with and to follow along – not
    to mention being able to create your own topics. Of course, this post
    and its comments will always be here for reference.

    I’ll keep you posted on transfer developments. In the meantime, here’s a link to the forum.

    Thank you for your loyal readership, and let’s keep moving forward – together!


  • chipur August 26, 2011, 10:37 pm

    Hi chipur readers!

    Well, I went ahead and did it. Comments to this article are now closed. Not to worry, the article will always be here, as well as the comments. Just can’t comment anew. Come on! Head on over to the forum.

  • chipur August 26, 2011, 10:37 pm

    Hi chipur readers!

    Well, I went ahead and did it. Comments to this article are now closed. Not to worry, the article will always be here, as well as the comments. Just can’t comment anew. Come on! Head on over to the forum.

  • Vibrant August 27, 2011, 10:30 pm

    hi Bill, i used to visit a paxil forum (actually it’s a forum to help people get off paxil)  anyhow, i love your website and reading posts here, but it would be awesome if you could set it up similarly to the paxil site. i find myself scrolling all over the place to see new posts on the chipur website.  it would be great to have them organized..   of course, this would be a huge overhaul of your site and i’m sure would require a lot of work..anyhow, just thought i’d send you this link in case you were interested…best.  V

  • Vibrant August 27, 2011, 10:30 pm

    hi Bill, i used to visit a paxil forum (actually it’s a forum to help people get off paxil)  anyhow, i love your website and reading posts here, but it would be awesome if you could set it up similarly to the paxil site. i find myself scrolling all over the place to see new posts on the chipur website.  it would be great to have them organized..   of course, this would be a huge overhaul of your site and i’m sure would require a lot of work..anyhow, just thought i’d send you this link in case you were interested…best.  V

  • Bill White November 19, 2014, 11:10 am

    Thanks for posting! Bill (Chipur)